Prostaglandin I Synthase (PTGIS)
PGIS; CYP8A1; Prostacyclin Synthase; Prostacycline Synthetase; Prostagladin I2 Synthetase; PGI2 Synthetase; Cytochrome P450,Family 8,Subfamily A,Polypeptide 1
Prostaglandin I2 (prostacyclin) synthase is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostaglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW072Hu01 | Recombinant Prostaglandin I Synthase (PTGIS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW072Hu01 | Monoclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IP. |
| PAW072Hu01 | Polyclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW072Hu01 | CLIA Kit for Prostaglandin I Synthase (PTGIS) | CLIA assay for Antigen Detection |
| ELW072Hu01 | ELISA Kit for Prostaglandin I Synthase (PTGIS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW072Mu01 | Recombinant Prostaglandin I Synthase (PTGIS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW072Mu01 | Monoclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IP. |
| PAW072Mu01 | Polyclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW072Mu01 | CLIA Kit for Prostaglandin I Synthase (PTGIS) | CLIA assay for Antigen Detection |
| ELW072Mu01 | ELISA Kit for Prostaglandin I Synthase (PTGIS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW072Ra01 | Recombinant Prostaglandin I Synthase (PTGIS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW072Ra01 | Monoclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IP. |
| PAW072Ra01 | Polyclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW072Ra01 | CLIA Kit for Prostaglandin I Synthase (PTGIS) | CLIA assay for Antigen Detection |
| ELW072Ra01 | ELISA Kit for Prostaglandin I Synthase (PTGIS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW072Ca01 | Recombinant Prostaglandin I Synthase (PTGIS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW072Ca01 | Monoclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IP. |
| PAW072Ca01 | Polyclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW072Ca01 | CLIA Kit for Prostaglandin I Synthase (PTGIS) | CLIA assay for Antigen Detection |
| ELW072Ca01 | ELISA Kit for Prostaglandin I Synthase (PTGIS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW072Po01 | Recombinant Prostaglandin I Synthase (PTGIS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW072Po01 | Monoclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IP. |
| PAW072Po01 | Polyclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW072Po01 | CLIA Kit for Prostaglandin I Synthase (PTGIS) | CLIA assay for Antigen Detection |
| ELW072Po01 | ELISA Kit for Prostaglandin I Synthase (PTGIS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW072Bo01 | Recombinant Prostaglandin I Synthase (PTGIS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW072Bo01 | Monoclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IP. |
| PAW072Bo01 | Polyclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW072Bo01 | CLIA Kit for Prostaglandin I Synthase (PTGIS) | CLIA assay for Antigen Detection |
| ELW072Bo01 | ELISA Kit for Prostaglandin I Synthase (PTGIS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW072Rb01 | Recombinant Prostaglandin I Synthase (PTGIS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW072Rb01 | Monoclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IP. |
| PAW072Rb01 | Polyclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW072Rb01 | CLIA Kit for Prostaglandin I Synthase (PTGIS) | CLIA assay for Antigen Detection |
| ELW072Rb01 | ELISA Kit for Prostaglandin I Synthase (PTGIS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW072Mo01 | Recombinant Prostaglandin I Synthase (PTGIS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW072Mo01 | Monoclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IP. |
| PAW072Mo01 | Polyclonal Antibody to Prostaglandin I Synthase (PTGIS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW072Mo01 | CLIA Kit for Prostaglandin I Synthase (PTGIS) | CLIA assay for Antigen Detection |
| ELW072Mo01 | ELISA Kit for Prostaglandin I Synthase (PTGIS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and expression of human prostacyclin synthase."
Biochem. Biophys. Res. Commun. 200:1728-1734(1994) [PubMed] [Europe PMC] [Abstract]
"Characterization of new mutations in the coding sequence and 5'-untranslated region of the human prostacyclin synthase gene (CYP8A1)."
Hum. Genet. 108:148-155(2001) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension."
Biochem. Biophys. Res. Commun. 297:1135-1139(2002) [PubMed] [Europe PMC] [Abstract]
"Analysis of genetic polymorphism and biochemical characterization of a functionally decreased variant in prostacyclin synthase gene (CYP8A1) in humans."
Arch. Biochem. Biophys. 569C:10-18(2015) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the human prostacyclin synthase."
J. Mol. Biol. 364:266-274(2006) [PubMed] [Europe PMC] [Abstract]