Metallothionein 3 (MT3)
GIF; GIFB; GRIF; Growth Inhibitory Factor; Neurotrophic
Metallothionein-3 is a protein was discovered in 1957 by Vallee and Margoshe from purification of a Cd-binding protein from horse (equine) renal cortex .
MTs function is not clear, but experimental data suggest MTs may provide protection against metal toxicity, be involved in regulation of physiological metals (Zn and Cu) and provide protection against oxidative stress. There are four main isoforms expressed in humans. In the human body, large quantities are synthesised primarily in the liver and kidneys.
Their production is dependent on availability of the dietary minerals, as zinc, copper and selenium, and the amino acids histidine and cysteine.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW069Hu01 | Recombinant Metallothionein 3 (MT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW069Hu01 | Monoclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IP. |
| PAW069Hu01 | Polyclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW069Hu01 | CLIA Kit for Metallothionein 3 (MT3) | CLIA assay for Antigen Detection |
| ELW069Hu01 | ELISA Kit for Metallothionein 3 (MT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW069Mu01 | Recombinant Metallothionein 3 (MT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW069Mu01 | Monoclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IP. |
| PAW069Mu01 | Polyclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW069Mu01 | CLIA Kit for Metallothionein 3 (MT3) | CLIA assay for Antigen Detection |
| ELW069Mu01 | ELISA Kit for Metallothionein 3 (MT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW069Ra01 | Recombinant Metallothionein 3 (MT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW069Ra01 | Monoclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IP. |
| PAW069Ra01 | Polyclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW069Ra01 | CLIA Kit for Metallothionein 3 (MT3) | CLIA assay for Antigen Detection |
| ELW069Ra01 | ELISA Kit for Metallothionein 3 (MT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW069Ca01 | Recombinant Metallothionein 3 (MT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW069Ca01 | Monoclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IP. |
| PAW069Ca01 | Polyclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW069Ca01 | CLIA Kit for Metallothionein 3 (MT3) | CLIA assay for Antigen Detection |
| ELW069Ca01 | ELISA Kit for Metallothionein 3 (MT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW069Po01 | Recombinant Metallothionein 3 (MT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW069Po01 | Monoclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IP. |
| PAW069Po01 | Polyclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW069Po01 | CLIA Kit for Metallothionein 3 (MT3) | CLIA assay for Antigen Detection |
| ELW069Po01 | ELISA Kit for Metallothionein 3 (MT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW069Bo01 | Recombinant Metallothionein 3 (MT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW069Bo01 | Monoclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IP. |
| PAW069Bo01 | Polyclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW069Bo01 | CLIA Kit for Metallothionein 3 (MT3) | CLIA assay for Antigen Detection |
| ELW069Bo01 | ELISA Kit for Metallothionein 3 (MT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW069Rb01 | Recombinant Metallothionein 3 (MT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW069Rb01 | Monoclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IP. |
| PAW069Rb01 | Polyclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW069Rb01 | CLIA Kit for Metallothionein 3 (MT3) | CLIA assay for Antigen Detection |
| ELW069Rb01 | ELISA Kit for Metallothionein 3 (MT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW069Mo01 | Recombinant Metallothionein 3 (MT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW069Mo01 | Monoclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IP. |
| PAW069Mo01 | Polyclonal Antibody to Metallothionein 3 (MT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW069Mo01 | CLIA Kit for Metallothionein 3 (MT3) | CLIA assay for Antigen Detection |
| ELW069Mo01 | ELISA Kit for Metallothionein 3 (MT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein."
Neuron 7:337-347(1991) [PubMed] [Europe PMC] [Abstract]
"MT-III, a brain-specific member of the metallothionein gene family."
Proc. Natl. Acad. Sci. U.S.A. 89:6333-6337(1992) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease."
EMBO J. 11:4843-4850(1992) [PubMed] [Europe PMC] [Abstract]
"Structures of the human and mouse growth inhibitory factor-encoding genes."
Gene 144:283-287(1994) [PubMed] [Europe PMC] [Abstract]
"Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes."
Biochem. Biophys. Res. Commun. 214:639-645(1995) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]