Cyclic ADP Ribose Hydrolase (cADPRH)
CD38; ADPRC 1; c-ADPRH; T10; p45; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1
CD38 (cluster of differentiation 38) is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4 , CD8 , B and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.In humans, the CD38 protein is encoded by the CD38 gene which located on chromosome 4. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+.The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW060Hu01 | Recombinant Cyclic ADP Ribose Hydrolase (cADPRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW060Hu01 | Monoclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IP. |
| PAW060Hu01 | Polyclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW060Hu01 | CLIA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | CLIA assay for Antigen Detection |
| ELW060Hu01 | ELISA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW060Mu01 | Recombinant Cyclic ADP Ribose Hydrolase (cADPRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW060Mu01 | Monoclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IP. |
| PAW060Mu01 | Polyclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW060Mu01 | CLIA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | CLIA assay for Antigen Detection |
| ELW060Mu01 | ELISA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW060Ra01 | Recombinant Cyclic ADP Ribose Hydrolase (cADPRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW060Ra01 | Monoclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IP. |
| PAW060Ra01 | Polyclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW060Ra01 | CLIA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | CLIA assay for Antigen Detection |
| ELW060Ra01 | ELISA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW060Ca01 | Recombinant Cyclic ADP Ribose Hydrolase (cADPRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW060Ca01 | Monoclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IP. |
| PAW060Ca01 | Polyclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW060Ca01 | CLIA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | CLIA assay for Antigen Detection |
| ELW060Ca01 | ELISA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW060Po01 | Recombinant Cyclic ADP Ribose Hydrolase (cADPRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW060Po01 | Monoclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IP. |
| PAW060Po01 | Polyclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW060Po01 | CLIA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | CLIA assay for Antigen Detection |
| ELW060Po01 | ELISA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW060Bo01 | Recombinant Cyclic ADP Ribose Hydrolase (cADPRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW060Bo01 | Monoclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IP. |
| PAW060Bo01 | Polyclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW060Bo01 | CLIA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | CLIA assay for Antigen Detection |
| ELW060Bo01 | ELISA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW060Rb01 | Recombinant Cyclic ADP Ribose Hydrolase (cADPRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW060Rb01 | Monoclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IP. |
| PAW060Rb01 | Polyclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW060Rb01 | CLIA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | CLIA assay for Antigen Detection |
| ELW060Rb01 | ELISA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW060Mo01 | Recombinant Cyclic ADP Ribose Hydrolase (cADPRH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW060Mo01 | Monoclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IP. |
| PAW060Mo01 | Polyclonal Antibody to Cyclic ADP Ribose Hydrolase (cADPRH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW060Mo01 | CLIA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | CLIA assay for Antigen Detection |
| ELW060Mo01 | ELISA Kit for Cyclic ADP Ribose Hydrolase (cADPRH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation."
J. Immunol. 144:2811-2815(1990) [PubMed] [Europe PMC] [Abstract]
"Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing."
Gene 186:285-292(1997) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38."
Trends Biochem. Sci. 17:495-495(1992) [PubMed] [Europe PMC] [Abstract]
"Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP."
J. Biol. Chem. 268:26052-26054(1993) [PubMed] [Europe PMC] [Abstract]
"Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38."
J. Biol. Chem. 269:28555-28557(1994) [PubMed] [Europe PMC] [Abstract]
"An unappreciated role for RNA surveillance."
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
"NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases."
Biochem. Biophys. Res. Commun. 345:573-580(2006) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human CD38 extracellular domain."
Structure 13:1331-1339(2005) [PubMed] [Europe PMC] [Abstract]
"A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro."
Diabetologia 41:1024-1028(1998) [PubMed] [Europe PMC] [Abstract]