Epidermal Growth Factor Receptor (EGFR)
ErbB-1; ErbB1; ER1; ERB-B1; MENA; HER1; Erythroblastic Leukemia Viral(v-Erb-B)oncogene Homolog,Avian; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. EGFR exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor α (TGFα). ErbB2 has no known direct activating ligand, and may be in an activated state constitutively or become active upon heterodimerization with other family members such as EGFR.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW055Hu01 | Recombinant Epidermal Growth Factor Receptor (EGFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW055Hu01 | Monoclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IP. |
| PAW055Hu01 | Polyclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW055Hu01 | CLIA Kit for Epidermal Growth Factor Receptor (EGFR) | CLIA assay for Antigen Detection |
| ELW055Hu01 | ELISA Kit for Epidermal Growth Factor Receptor (EGFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW055Mu01 | Recombinant Epidermal Growth Factor Receptor (EGFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW055Mu01 | Monoclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IP. |
| PAW055Mu01 | Polyclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW055Mu01 | CLIA Kit for Epidermal Growth Factor Receptor (EGFR) | CLIA assay for Antigen Detection |
| ELW055Mu01 | ELISA Kit for Epidermal Growth Factor Receptor (EGFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW055Ra01 | Recombinant Epidermal Growth Factor Receptor (EGFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW055Ra01 | Monoclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IP. |
| PAW055Ra01 | Polyclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW055Ra01 | CLIA Kit for Epidermal Growth Factor Receptor (EGFR) | CLIA assay for Antigen Detection |
| ELW055Ra01 | ELISA Kit for Epidermal Growth Factor Receptor (EGFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW055Ca01 | Recombinant Epidermal Growth Factor Receptor (EGFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW055Ca01 | Monoclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IP. |
| PAW055Ca01 | Polyclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW055Ca01 | CLIA Kit for Epidermal Growth Factor Receptor (EGFR) | CLIA assay for Antigen Detection |
| ELW055Ca01 | ELISA Kit for Epidermal Growth Factor Receptor (EGFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW055Po01 | Recombinant Epidermal Growth Factor Receptor (EGFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW055Po01 | Monoclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IP. |
| PAW055Po01 | Polyclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW055Po01 | CLIA Kit for Epidermal Growth Factor Receptor (EGFR) | CLIA assay for Antigen Detection |
| ELW055Po01 | ELISA Kit for Epidermal Growth Factor Receptor (EGFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW055Bo01 | Recombinant Epidermal Growth Factor Receptor (EGFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW055Bo01 | Monoclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IP. |
| PAW055Bo01 | Polyclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW055Bo01 | CLIA Kit for Epidermal Growth Factor Receptor (EGFR) | CLIA assay for Antigen Detection |
| ELW055Bo01 | ELISA Kit for Epidermal Growth Factor Receptor (EGFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW055Rb01 | Recombinant Epidermal Growth Factor Receptor (EGFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW055Rb01 | Monoclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IP. |
| PAW055Rb01 | Polyclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW055Rb01 | CLIA Kit for Epidermal Growth Factor Receptor (EGFR) | CLIA assay for Antigen Detection |
| ELW055Rb01 | ELISA Kit for Epidermal Growth Factor Receptor (EGFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW055Mo01 | Recombinant Epidermal Growth Factor Receptor (EGFR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW055Mo01 | Monoclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IP. |
| PAW055Mo01 | Polyclonal Antibody to Epidermal Growth Factor Receptor (EGFR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW055Mo01 | CLIA Kit for Epidermal Growth Factor Receptor (EGFR) | CLIA assay for Antigen Detection |
| ELW055Mo01 | ELISA Kit for Epidermal Growth Factor Receptor (EGFR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells."
Nature 309:418-425(1984) [PubMed] [Europe PMC] [Abstract]
"Possible role of variant RNA transcripts in the regulation of epidermal growth factor receptor expression in human placenta."
Mol. Reprod. Dev. 41:149-156(1995) [PubMed] [Europe PMC] [Abstract]
"A 1.8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptor."
Nucleic Acids Res. 24:4050-4056(1996) [PubMed] [Europe PMC] [Abstract]
"Expression of a truncated epidermal growth factor receptor-like protein (TEGFR) in ovarian cancer."
Gynecol. Oncol. 65:36-41(1997) [PubMed] [Europe PMC] [Abstract]
"Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms."
Genomics 71:1-20(2001) [PubMed] [Europe PMC] [Abstract]
"Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells."
Science 224:843-848(1984) [PubMed] [Europe PMC] [Abstract]
"Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells."
Nature 309:806-810(1984) [PubMed] [Europe PMC] [Abstract]
"Isolation of an evolutionarily conserved epidermal growth factor receptor cDNA from human A431 carcinoma cells."
Biochem. Biophys. Res. Commun. 124:125-132(1984) [PubMed] [Europe PMC] [Abstract]
"The human EGF receptor gene: structure of the 110 kb locus and identification of sequences regulating its transcription."
Oncogene Res. 1:375-396(1987) [PubMed] [Europe PMC] [Abstract]
"Contributory effects of de novo transcription and premature transcript termination in the regulation of human epidermal growth factor receptor proto-oncogene RNA synthesis."
J. Biol. Chem. 266:1746-1753(1991) [PubMed] [Europe PMC] [Abstract]
"Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene."
Proc. Natl. Acad. Sci. U.S.A. 82:4920-4924(1985) [PubMed] [Europe PMC] [Abstract]
"Production of an epidermal growth factor receptor-related protein."
Science 224:294-297(1984) [PubMed] [Europe PMC] [Abstract]