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Ficolin 1 (FCN1)

FCNM; Collagen/fibrinogen domain-containing protein 1; Ficolin-alpha; Ficolin-A; M-ficolin

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct.

Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW026Hu01 Recombinant Ficolin 1 (FCN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW026Hu01 Monoclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
PAW026Hu01 Polyclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IF.
Assay Kits CLW026Hu01 CLIA Kit for Ficolin 1 (FCN1) CLIA assay for Antigen Detection
ELW026Hu01 ELISA Kit for Ficolin 1 (FCN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW026Mu01 Recombinant Ficolin 1 (FCN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW026Mu01 Monoclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
PAW026Mu01 Polyclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IF.
Assay Kits CLW026Mu01 CLIA Kit for Ficolin 1 (FCN1) CLIA assay for Antigen Detection
ELW026Mu01 ELISA Kit for Ficolin 1 (FCN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW026Ra01 Recombinant Ficolin 1 (FCN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW026Ra01 Monoclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
PAW026Ra01 Polyclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IF.
Assay Kits CLW026Ra01 CLIA Kit for Ficolin 1 (FCN1) CLIA assay for Antigen Detection
ELW026Ra01 ELISA Kit for Ficolin 1 (FCN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW026Ca01 Recombinant Ficolin 1 (FCN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW026Ca01 Monoclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
PAW026Ca01 Polyclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IF.
Assay Kits CLW026Ca01 CLIA Kit for Ficolin 1 (FCN1) CLIA assay for Antigen Detection
ELW026Ca01 ELISA Kit for Ficolin 1 (FCN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW026Po01 Recombinant Ficolin 1 (FCN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW026Po01 Monoclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
PAW026Po01 Polyclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IF.
Assay Kits CLW026Po01 CLIA Kit for Ficolin 1 (FCN1) CLIA assay for Antigen Detection
ELW026Po01 ELISA Kit for Ficolin 1 (FCN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW026Bo01 Recombinant Ficolin 1 (FCN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW026Bo01 Monoclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
PAW026Bo01 Polyclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IF.
Assay Kits CLW026Bo01 CLIA Kit for Ficolin 1 (FCN1) CLIA assay for Antigen Detection
ELW026Bo01 ELISA Kit for Ficolin 1 (FCN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW026Rb01 Recombinant Ficolin 1 (FCN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW026Rb01 Monoclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
PAW026Rb01 Polyclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IF.
Assay Kits CLW026Rb01 CLIA Kit for Ficolin 1 (FCN1) CLIA assay for Antigen Detection
ELW026Rb01 ELISA Kit for Ficolin 1 (FCN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW026Mo01 Recombinant Ficolin 1 (FCN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW026Mo01 Monoclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
PAW026Mo01 Polyclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IF.
Assay Kits CLW026Mo01 CLIA Kit for Ficolin 1 (FCN1) CLIA assay for Antigen Detection
ELW026Mo01 ELISA Kit for Ficolin 1 (FCN1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9."
Biochem. J. 313:473-478(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1."
J. Biochem. 120:745-751(1996) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense."
J. Immunol. 185:6899-6910(2010) [PubMed] [Europe PMC] [Abstract]

"Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain."
J. Leukoc. Biol. 88:145-158(2010) [PubMed] [Europe PMC] [Abstract]

"Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain."
J. Biol. Chem. 282:3889-3895(2007) [PubMed] [Europe PMC] [Abstract]

"Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch."
J. Biol. Chem. 282:35814-35820(2007) [PubMed] [Europe PMC] [Abstract]

"Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin."
J. Biol. Chem. 285:6612-6622(2010) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]