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Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17)

CD269; BCM; BCMA; B-cell maturation protein

Tumor necrosis factor receptor superfamily member 17 is  a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b, and to lead to NF-kappaB and MAPK8/JNK activation.

This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.The patient from whose tumor cells the 4;16 translocation was derived had a chronic intestinal malabsorption syndrome. Histologic and immunohistochemical studies demonstrated a lymphoproliferative syndrome of mature T cells.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW022Hu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW022Hu01 Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IP.
PAW022Hu01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IF.
Assay Kits CLW022Hu01 CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) CLIA assay for Antigen Detection
ELW022Hu01 ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW022Mu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW022Mu01 Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IP.
PAW022Mu01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IF.
Assay Kits CLW022Mu01 CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) CLIA assay for Antigen Detection
ELW022Mu01 ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW022Ra01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW022Ra01 Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IP.
PAW022Ra01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IF.
Assay Kits CLW022Ra01 CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) CLIA assay for Antigen Detection
ELW022Ra01 ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW022Ca01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW022Ca01 Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IP.
PAW022Ca01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IF.
Assay Kits CLW022Ca01 CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) CLIA assay for Antigen Detection
ELW022Ca01 ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW022Po01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW022Po01 Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IP.
PAW022Po01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IF.
Assay Kits CLW022Po01 CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) CLIA assay for Antigen Detection
ELW022Po01 ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW022Bo01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW022Bo01 Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IP.
PAW022Bo01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IF.
Assay Kits CLW022Bo01 CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) CLIA assay for Antigen Detection
ELW022Bo01 ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW022Rb01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW022Rb01 Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IP.
PAW022Rb01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IF.
Assay Kits CLW022Rb01 CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) CLIA assay for Antigen Detection
ELW022Rb01 ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW022Mo01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW022Mo01 Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IP.
PAW022Mo01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) WB; IHC; ICC; IF.
Assay Kits CLW022Mo01 CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) CLIA assay for Antigen Detection
ELW022Mo01 ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma."
EMBO J. 11:3897-3904(1992) [PubMed] [Europe PMC] [Abstract]

"The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed."
Nucleic Acids Res. 22:1147-1154(1994) [PubMed] [Europe PMC] [Abstract]

"Presence of four major haplotypes in human BCMA gene: lack of association with systemic lupus erythematosus and rheumatoid arthritis."
Genes Immun. 2:276-279(2001) [PubMed] [Europe PMC] [Abstract]

"Identification of new splice variants of the genes BAFF and BCMA."
Mol. Immunol. 45:1179-1183(2008) [PubMed] [Europe PMC] [Abstract]

"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."
Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase."
J. Immunol. 165:1322-1330(2000) [PubMed] [Europe PMC] [Abstract]

"TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease."
Nature 404:995-999(2000) [PubMed] [Europe PMC] [Abstract]

"APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity."
Nat. Immunol. 1:252-256(2000) [PubMed] [Europe PMC] [Abstract]

"B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1."
Proc. Natl. Acad. Sci. U.S.A. 97:9156-9161(2000) [PubMed] [Europe PMC] [Abstract]

"Ligand-receptor binding revealed by the TNF family member TALL-1."
Nature 423:49-56(2003) [PubMed] [Europe PMC] [Abstract]

"Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding."
J. Biol. Chem. 280:7218-7227(2005) [PubMed] [Europe PMC] [Abstract]