Osteonectin (ON)
SPARC; BM-40; Secreted Protein,Acidic,Cysteine-Rich; Basement-membrane protein 40; Secreted protein acidic and rich in cysteine
Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. Some current research shows a correlation between osteonectin over expression and ampullary cancers and chronic pancreatitis. Osteonectin is an acidic, secreted extracellular matrix glycoprotein that plays a vital role in bone mineralization, cell-matrix interactions, and collagen binding. Osteonectin also increases the production and activity of matrix metalloproteinases, a function important to invading cancer cells within bone. Additional functions of osteonectin beneficial to tumor cells include angiogenesis, proliferation and migration.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW021Hu01 | Recombinant Osteonectin (ON) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW021Hu01 | Monoclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IP. |
| PAW021Hu01 | Polyclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW021Hu01 | CLIA Kit for Osteonectin (ON) | CLIA assay for Antigen Detection |
| ELW021Hu01 | ELISA Kit for Osteonectin (ON) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW021Mu01 | Recombinant Osteonectin (ON) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW021Mu01 | Monoclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IP. |
| PAW021Mu01 | Polyclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW021Mu01 | CLIA Kit for Osteonectin (ON) | CLIA assay for Antigen Detection |
| ELW021Mu01 | ELISA Kit for Osteonectin (ON) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW021Ra01 | Recombinant Osteonectin (ON) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW021Ra01 | Monoclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IP. |
| PAW021Ra01 | Polyclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW021Ra01 | CLIA Kit for Osteonectin (ON) | CLIA assay for Antigen Detection |
| ELW021Ra01 | ELISA Kit for Osteonectin (ON) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW021Ca01 | Recombinant Osteonectin (ON) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW021Ca01 | Monoclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IP. |
| PAW021Ca01 | Polyclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW021Ca01 | CLIA Kit for Osteonectin (ON) | CLIA assay for Antigen Detection |
| ELW021Ca01 | ELISA Kit for Osteonectin (ON) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW021Po01 | Recombinant Osteonectin (ON) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW021Po01 | Monoclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IP. |
| PAW021Po01 | Polyclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW021Po01 | CLIA Kit for Osteonectin (ON) | CLIA assay for Antigen Detection |
| ELW021Po01 | ELISA Kit for Osteonectin (ON) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW021Bo01 | Recombinant Osteonectin (ON) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW021Bo01 | Monoclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IP. |
| PAW021Bo01 | Polyclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW021Bo01 | CLIA Kit for Osteonectin (ON) | CLIA assay for Antigen Detection |
| ELW021Bo01 | ELISA Kit for Osteonectin (ON) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW021Rb01 | Recombinant Osteonectin (ON) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW021Rb01 | Monoclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IP. |
| PAW021Rb01 | Polyclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW021Rb01 | CLIA Kit for Osteonectin (ON) | CLIA assay for Antigen Detection |
| ELW021Rb01 | ELISA Kit for Osteonectin (ON) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW021Mo01 | Recombinant Osteonectin (ON) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW021Mo01 | Monoclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IP. |
| PAW021Mo01 | Polyclonal Antibody to Osteonectin (ON) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW021Mo01 | CLIA Kit for Osteonectin (ON) | CLIA assay for Antigen Detection |
| ELW021Mo01 | ELISA Kit for Osteonectin (ON) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin)."
FEBS Lett. 236:352-356(1988) [PubMed] [Europe PMC] [Abstract]
"Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33."
Genomics 2:37-47(1988) [PubMed] [Europe PMC] [Abstract]
"Structure of human osteonectin based upon analysis of cDNA and genomic sequences."
Biochemistry 28:6483-6491(1989) [PubMed] [Europe PMC] [Abstract]
"Structure and expression of osteonectin mRNA in human tissue."
Connect. Tissue Res. 24:17-28(1990) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone."
J. Biol. Chem. 262:9702-9708(1987) [PubMed] [Europe PMC] [Abstract]
"Human platelet osteonectin: release, surface expression, and partial characterization."
Blood 75:1105-1113(1990) [PubMed] [Europe PMC] [Abstract]
"Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane."
Am. J. Pathol. 132:345-355(1988) [PubMed] [Europe PMC] [Abstract]
"Immunolocalization of SPARC, tenascin, and thrombospondin in pulmonary fibrosis."
Am. J. Pathol. 147:1759-1769(1995) [PubMed] [Europe PMC] [Abstract]
"BM-40 (osteonectin, SPARC) is expressed both in the epidermal and in the dermal compartment of adult human skin."
J. Invest. Dermatol. 110:122-126(1998) [PubMed] [Europe PMC] [Abstract]
"Structure of a novel extracellular Ca(2+)-binding module in BM-40."
Nat. Struct. Biol. 3:67-73(1996) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40."
EMBO J. 16:3778-3786(1997) [PubMed] [Europe PMC] [Abstract]
"Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin."
EMBO J. 17:1625-1634(1998) [PubMed] [Europe PMC] [Abstract]