Neuropeptide S (NPS)

NP-S

SPN	W016
HGNC	33940
MGI	3642232
PubMed	15312648
UniProt	P0C0P6
Wiki	NPS

Neuropeptide S (NPS) is a neuropeptide found in human and mammalian brain, mainly produced by neurons in the amygdala and between Barrington's nucleus and the locus coeruleus, although NPS-responsive neurons extend projections into many other brain areas.

NPS binds specifically to a newly de-orphaned G protein-coupled receptor, NPSR. Animal studies show that NPS suppresses anxiety and induces wakefulness and displays significant role in the extinction of conditioned fear. The non-peptide NPS receptor antagonist SHA-68 blocks the effects of NPS in animals and is anxiogenic. Several peptide derived NPS agonists and antagonists have also been developed.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW016Hu01	Recombinant Neuropeptide S (NPS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW016Hu01	Monoclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IP.
Antibodies	PAW016Hu01	Polyclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IF.
Assay Kits	CLW016Hu01	CLIA Kit for Neuropeptide S (NPS)	CLIA assay for Antigen Detection
Assay Kits	ELW016Hu01	ELISA Kit for Neuropeptide S (NPS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW016Mu01	Recombinant Neuropeptide S (NPS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW016Mu01	Monoclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IP.
Antibodies	PAW016Mu01	Polyclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IF.
Assay Kits	CLW016Mu01	CLIA Kit for Neuropeptide S (NPS)	CLIA assay for Antigen Detection
Assay Kits	ELW016Mu01	ELISA Kit for Neuropeptide S (NPS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW016Ra01	Recombinant Neuropeptide S (NPS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW016Ra01	Monoclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IP.
Antibodies	PAW016Ra01	Polyclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IF.
Assay Kits	CLW016Ra01	CLIA Kit for Neuropeptide S (NPS)	CLIA assay for Antigen Detection
Assay Kits	ELW016Ra01	ELISA Kit for Neuropeptide S (NPS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW016Ca01	Recombinant Neuropeptide S (NPS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW016Ca01	Monoclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IP.
Antibodies	PAW016Ca01	Polyclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IF.
Assay Kits	CLW016Ca01	CLIA Kit for Neuropeptide S (NPS)	CLIA assay for Antigen Detection
Assay Kits	ELW016Ca01	ELISA Kit for Neuropeptide S (NPS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW016Po01	Recombinant Neuropeptide S (NPS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW016Po01	Monoclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IP.
Antibodies	PAW016Po01	Polyclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IF.
Assay Kits	CLW016Po01	CLIA Kit for Neuropeptide S (NPS)	CLIA assay for Antigen Detection
Assay Kits	ELW016Po01	ELISA Kit for Neuropeptide S (NPS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW016Bo01	Recombinant Neuropeptide S (NPS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW016Bo01	Monoclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IP.
Antibodies	PAW016Bo01	Polyclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IF.
Assay Kits	CLW016Bo01	CLIA Kit for Neuropeptide S (NPS)	CLIA assay for Antigen Detection
Assay Kits	ELW016Bo01	ELISA Kit for Neuropeptide S (NPS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW016Rb01	Recombinant Neuropeptide S (NPS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW016Rb01	Monoclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IP.
Antibodies	PAW016Rb01	Polyclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IF.
Assay Kits	CLW016Rb01	CLIA Kit for Neuropeptide S (NPS)	CLIA assay for Antigen Detection
Assay Kits	ELW016Rb01	ELISA Kit for Neuropeptide S (NPS)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPW016Mo01	Recombinant Neuropeptide S (NPS)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAW016Mo01	Monoclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IP.
Antibodies	PAW016Mo01	Polyclonal Antibody to Neuropeptide S (NPS)	WB; IHC; ICC; IF.
Assay Kits	CLW016Mo01	CLIA Kit for Neuropeptide S (NPS)	CLIA assay for Antigen Detection
Assay Kits	ELW016Mo01	ELISA Kit for Neuropeptide S (NPS)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Novel G protein-coupled receptor protein and its DNA."
Patent number WO0231145, 18-APR-2002

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects."
Neuron 43:487-497(2004) [PubMed] [Europe PMC] [Abstract]

"Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I."
J. Biol. Chem. 281:24704-24712(2006) [PubMed] [Europe PMC] [Abstract]