Islet Amyloid Polypeptide (IAPP)
IAP; DAP; Amylin; Insulinoma Amyloid Polypeptide; Diabetes-associated peptide
Islet, or insulinoma, amyloid polypeptide (IAPP, or amylin) is commonly found in pancreatic islets of patients suffering diabetes mellitus type 2, or harboring an insulinoma. While the association of amylin with the development of type 2 diabetes has been known for some time, a direct causative role for amylin has been harder to establish.
Recent results suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in insulin-producing beta cells, an effect that may be relevant to the development of type 2 diabetes. Finally, a recent study reported a synergistic effect for weight loss with leptin and amylin coadministration in diet-induced obese rats by restoring hypothalamic sensitivity to leptin .
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV999Hu01 | Recombinant Islet Amyloid Polypeptide (IAPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV999Hu01 | Monoclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IP. |
| PAV999Hu01 | Polyclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV999Hu01 | CLIA Kit for Islet Amyloid Polypeptide (IAPP) | CLIA assay for Antigen Detection |
| ELV999Hu01 | ELISA Kit for Islet Amyloid Polypeptide (IAPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV999Mu01 | Recombinant Islet Amyloid Polypeptide (IAPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV999Mu01 | Monoclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IP. |
| PAV999Mu01 | Polyclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV999Mu01 | CLIA Kit for Islet Amyloid Polypeptide (IAPP) | CLIA assay for Antigen Detection |
| ELV999Mu01 | ELISA Kit for Islet Amyloid Polypeptide (IAPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV999Ra01 | Recombinant Islet Amyloid Polypeptide (IAPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV999Ra01 | Monoclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IP. |
| PAV999Ra01 | Polyclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV999Ra01 | CLIA Kit for Islet Amyloid Polypeptide (IAPP) | CLIA assay for Antigen Detection |
| ELV999Ra01 | ELISA Kit for Islet Amyloid Polypeptide (IAPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV999Ca01 | Recombinant Islet Amyloid Polypeptide (IAPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV999Ca01 | Monoclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IP. |
| PAV999Ca01 | Polyclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV999Ca01 | CLIA Kit for Islet Amyloid Polypeptide (IAPP) | CLIA assay for Antigen Detection |
| ELV999Ca01 | ELISA Kit for Islet Amyloid Polypeptide (IAPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV999Po01 | Recombinant Islet Amyloid Polypeptide (IAPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV999Po01 | Monoclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IP. |
| PAV999Po01 | Polyclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV999Po01 | CLIA Kit for Islet Amyloid Polypeptide (IAPP) | CLIA assay for Antigen Detection |
| ELV999Po01 | ELISA Kit for Islet Amyloid Polypeptide (IAPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV999Bo01 | Recombinant Islet Amyloid Polypeptide (IAPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV999Bo01 | Monoclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IP. |
| PAV999Bo01 | Polyclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV999Bo01 | CLIA Kit for Islet Amyloid Polypeptide (IAPP) | CLIA assay for Antigen Detection |
| ELV999Bo01 | ELISA Kit for Islet Amyloid Polypeptide (IAPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV999Rb01 | Recombinant Islet Amyloid Polypeptide (IAPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV999Rb01 | Monoclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IP. |
| PAV999Rb01 | Polyclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV999Rb01 | CLIA Kit for Islet Amyloid Polypeptide (IAPP) | CLIA assay for Antigen Detection |
| ELV999Rb01 | ELISA Kit for Islet Amyloid Polypeptide (IAPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV999Mo01 | Recombinant Islet Amyloid Polypeptide (IAPP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV999Mo01 | Monoclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IP. |
| PAV999Mo01 | Polyclonal Antibody to Islet Amyloid Polypeptide (IAPP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV999Mo01 | CLIA Kit for Islet Amyloid Polypeptide (IAPP) | CLIA assay for Antigen Detection |
| ELV999Mo01 | ELISA Kit for Islet Amyloid Polypeptide (IAPP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The complete islet amyloid polypeptide precursor is encoded by two exons."
FEBS Lett. 247:154-158(1989) [PubMed] [Europe PMC] [Abstract]
"Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary history."
Mol. Endocrinol. 3:1775-1781(1989) [PubMed] [Europe PMC] [Abstract]
"An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing."
J. Biol. Chem. 263:17243-17246(1988) [PubMed] [Europe PMC] [Abstract]
"The human islet amyloid polypeptide (IAPP) gene. Organization, chromosomal localization and functional identification of a promoter region."
FEBS Lett. 267:160-166(1990) [PubMed] [Europe PMC] [Abstract]
"Islet amyloid polypeptide: structure and upstream sequences of the IAPP gene in rat and man."
Biochim. Biophys. Acta 1087:235-240(1990) [PubMed] [Europe PMC] [Abstract]
"Characterization of the human islet amyloid polypeptide/amylin gene transcripts: identification of a new polyadenylation site."
Biochem. Biophys. Res. Commun. 189:1569-1577(1992) [PubMed] [Europe PMC] [Abstract]
"Cloning and expression of human islet amyloid polypeptide in cultured cells."
Biochem. Biophys. Res. Commun. 356:622-628(2007) [PubMed] [Europe PMC] [Abstract]
"Islet amyloid polypeptide: identification and chromosomal localization of the human gene."
FEBS Lett. 239:227-232(1988) [PubMed] [Europe PMC] [Abstract]
"Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients."
Proc. Natl. Acad. Sci. U.S.A. 84:8628-8632(1987) [PubMed] [Europe PMC] [Abstract]
"Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species."
FEBS Lett. 251:261-264(1989) [PubMed] [Europe PMC] [Abstract]
"Isolation and identification of islet amyloid polypeptide in normal human pancreas."
Regul. Pept. 31:179-186(1990) [PubMed] [Europe PMC] [Abstract]
"A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas."
Biochem. Biophys. Res. Commun. 140:827-831(1986) [PubMed] [Europe PMC] [Abstract]
"Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells."
Proc. Natl. Acad. Sci. U.S.A. 84:3881-3885(1987) [PubMed] [Europe PMC] [Abstract]
"Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus."
Proc. Natl. Acad. Sci. U.S.A. 86:9662-9666(1989) [PubMed] [Europe PMC] [Abstract]
"Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin."
Biochem. J. 275:785-788(1991) [PubMed] [Europe PMC] [Abstract]
"Conformational preferences of the amylin nucleation site in SDS micelles: an NMR study."
Biopolymers 69:29-41(2003) [PubMed] [Europe PMC] [Abstract]
"Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism."
Nature 443:870-874(2006) [PubMed] [Europe PMC] [Abstract]
"Dynamic alpha-helix structure of micelle-bound human amylin."
J. Biol. Chem. 284:11982-11991(2009) [PubMed] [Europe PMC] [Abstract]
"Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process."
Protein Sci. 18:1521-1530(2009) [PubMed] [Europe PMC] [Abstract]
"Missense mutation of amylin gene (S20G) in Japanese NIDDM patients."
Diabetes 45:1279-1281(1996) [PubMed] [Europe PMC] [Abstract]
"Role of S20G mutation of amylin gene in insulin secretion, insulin sensitivity, and type II diabetes mellitus in Taiwanese patients."
Diabetologia 41:1250-1251(1998) [PubMed] [Europe PMC] [Abstract]