Cholesteryl Ester Transfer Protein (CETP)

LTP; Lipid Transfer Protein; Plasma Lipid Transfer Protein; Cholesterylester Transfer Protein

SPN	V997
HGNC	1869
PubMed	17055779
UniProt	P11597
Wiki	CETP

Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It collects triglycerides from very low-density (VLDL) or low-density lipoproteins (LDL) and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa. Most of the time, however, CETP does a homoexchange, trading a triglyceride for a triglyceride or a cholesteryl ester for a cholesteryl ester.

Rare mutations leading to increased function of CETP have been linked to accelerated atherosclerosis. In contrast, a polymorphism (I405V) of the CETP gene leading to lower serum levels has also been linked to exceptional longevity

Reference

"Cloning and sequencing of human cholesteryl ester transfer protein cDNA."
Nature 327:632-634(1987) [PubMed] [Europe PMC] [Abstract]

"Organization of the human cholesteryl ester transfer protein gene."
Biochemistry 29:1372-1376(1990) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human cholesteryl ester transfer protein gene proximal promoter contains dietary cholesterol positive responsive elements and mediates expression in small intestine and periphery while predominant liver and spleen expression is controlled by 5'-distal sequences. Cis-acting sequences mapped in transgenic mice."
J. Biol. Chem. 271:31831-31838(1996) [PubMed] [Europe PMC] [Abstract]

"Sequencing of the cholesteryl ester transfer protein 5' regulatory region using artificial transposons."
Gene 197:101-107(1997) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

"Cholesteryl ester transfer proteins from different species do not have equivalent activities."
J. Lipid Res. 55:258-265(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules."
Nat. Struct. Mol. Biol. 14:106-113(2007) [PubMed] [Europe PMC] [Abstract]

"Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation."
N. Engl. J. Med. 323:1234-1238(1990) [PubMed] [Europe PMC] [Abstract]

"A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins."
J. Clin. Invest. 92:2060-2064(1993) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)

"Two novel missense mutations in the CETP gene in Japanese hyperalphalipoproteinemic subjects: high-throughput assay by Invader assay."
J. Lipid Res. 43:1011-1018(2002) [PubMed] [Europe PMC] [Abstract]

"Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors."
Hum. Mol. Genet. 12:2733-2743(2003) [PubMed] [Europe PMC] [Abstract]