Heat Shock Protein 90kDa Beta 1 (HSP90b1)
HSP90-B1; ECGP; GP96; GRP94; TRA1; Glycoprotein 96; Tumor Rejection Antigen(gp96)1;94 kDa glucose-regulated protein; Endoplasmin
Glycoprotein 96 is a cell surface protein that binds adenosine. Thus, gp96 is also called adenotin and it is similar to various stress-induced proteins. The gp96 serves as a natural adjuvant for chaperoning antigenic peptides into the immune surveillance pathways.Glycoprotein 96 Can Chaperone Both MHC Class I- and Class II-Restricted Epitopes for In Vivo Presentation, but Selectively Primes CD8 T Cell Effector Function gp96 facilitated the cross-presentation of a class I-restricted peptide and priming of effector function in cognate CD8 cells. Interestingly, gp96 also facilitated the in vivo presentation of a class II-restricted peptide; however, the resulting CD4 cell response did not involve the development of effector function. Gp96 is an inflammatory mediator that selectively primes CD8 cell effector function.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV988Hu01 | Recombinant Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV988Hu01 | Monoclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IP. |
| PAV988Hu01 | Polyclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV988Hu01 | CLIA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | CLIA assay for Antigen Detection |
| ELV988Hu01 | ELISA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV988Mu01 | Recombinant Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV988Mu01 | Monoclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IP. |
| PAV988Mu01 | Polyclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV988Mu01 | CLIA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | CLIA assay for Antigen Detection |
| ELV988Mu01 | ELISA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV988Ra01 | Recombinant Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV988Ra01 | Monoclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IP. |
| PAV988Ra01 | Polyclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV988Ra01 | CLIA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | CLIA assay for Antigen Detection |
| ELV988Ra01 | ELISA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV988Ca01 | Recombinant Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV988Ca01 | Monoclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IP. |
| PAV988Ca01 | Polyclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV988Ca01 | CLIA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | CLIA assay for Antigen Detection |
| ELV988Ca01 | ELISA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV988Po01 | Recombinant Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV988Po01 | Monoclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IP. |
| PAV988Po01 | Polyclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV988Po01 | CLIA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | CLIA assay for Antigen Detection |
| ELV988Po01 | ELISA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV988Bo01 | Recombinant Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV988Bo01 | Monoclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IP. |
| PAV988Bo01 | Polyclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV988Bo01 | CLIA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | CLIA assay for Antigen Detection |
| ELV988Bo01 | ELISA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV988Rb01 | Recombinant Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV988Rb01 | Monoclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IP. |
| PAV988Rb01 | Polyclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV988Rb01 | CLIA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | CLIA assay for Antigen Detection |
| ELV988Rb01 | ELISA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV988Mo01 | Recombinant Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV988Mo01 | Monoclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IP. |
| PAV988Mo01 | Polyclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV988Mo01 | CLIA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | CLIA assay for Antigen Detection |
| ELV988Mo01 | ELISA Kit for Heat Shock Protein 90kDa Beta 1 (HSP90b1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human homologue of murine tumor rejection antigen gp96: 5'-regulatory and coding regions and relationship to stress-induced proteins."
Proc. Natl. Acad. Sci. U.S.A. 87:5658-5662(1990) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Glucose-regulated protein (GRP94 and GRP78) genes share common regulatory domains and are coordinately regulated by common trans-acting factors."
Mol. Cell. Biol. 9:2153-2162(1989) [PubMed] [Europe PMC] [Abstract]
"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
"A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins."
Mol. Biol. Cell 13:4456-4469(2002) [PubMed] [Europe PMC] [Abstract]
"Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."
J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
Nat. Commun. 1:79-79(2010) [PubMed] [Europe PMC] [Abstract]
Erratum
Nat. Commun. 3:653-653(2012)
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
"OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD."
Nat. Cell Biol. 10:272-282(2008) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
"A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity."
PLoS Genet. 9:E1003210-E1003210(2013) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]