Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14)
CD258; TR2; HVEML; LIGHT; LTg; Herpes virus entry mediator ligand; Herpesvirus entry mediator ligand
Tumor necrosis factor ligand superfamily member 14 is a protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV984Hu01 | Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV984Hu01 | Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IP. |
| PAV984Hu01 | Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV984Hu01 | CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | CLIA assay for Antigen Detection |
| ELV984Hu01 | ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV984Mu01 | Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV984Mu01 | Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IP. |
| PAV984Mu01 | Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV984Mu01 | CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | CLIA assay for Antigen Detection |
| ELV984Mu01 | ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV984Ra01 | Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV984Ra01 | Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IP. |
| PAV984Ra01 | Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV984Ra01 | CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | CLIA assay for Antigen Detection |
| ELV984Ra01 | ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV984Ca01 | Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV984Ca01 | Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IP. |
| PAV984Ca01 | Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV984Ca01 | CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | CLIA assay for Antigen Detection |
| ELV984Ca01 | ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV984Po01 | Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV984Po01 | Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IP. |
| PAV984Po01 | Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV984Po01 | CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | CLIA assay for Antigen Detection |
| ELV984Po01 | ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV984Bo01 | Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV984Bo01 | Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IP. |
| PAV984Bo01 | Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV984Bo01 | CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | CLIA assay for Antigen Detection |
| ELV984Bo01 | ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV984Rb01 | Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV984Rb01 | Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IP. |
| PAV984Rb01 | Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV984Rb01 | CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | CLIA assay for Antigen Detection |
| ELV984Rb01 | ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV984Mo01 | Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV984Mo01 | Monoclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IP. |
| PAV984Mo01 | Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV984Mo01 | CLIA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | CLIA assay for Antigen Detection |
| ELV984Mo01 | ELISA Kit for Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator."
Immunity 8:21-30(1998) [PubMed] [Europe PMC] [Abstract]
"Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth."
J. Biol. Chem. 273:27548-27556(1998) [PubMed] [Europe PMC] [Abstract]
"Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis."
J. Immunol. 167:5122-5128(2001) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of LIGHT."
Submitted (MAY-2012) to the PDB data bank