Inhibin Beta A (INHbA)
INH-BA; INHB-A; EDF; FRP; Activin A,Activin AB Alpha Polypeptide; Activin beta-A chain; Erythroid differentiation protein
INHBA is a subunit of both activin and inhibin, two closely related glycoproteins with opposing biological effects.The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. Serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion. The beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV973Hu01 | Recombinant Inhibin Beta A (INHbA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV973Hu01 | Monoclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IP. |
| PAV973Hu01 | Polyclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV973Hu01 | CLIA Kit for Inhibin Beta A (INHbA) | CLIA assay for Antigen Detection |
| ELV973Hu01 | ELISA Kit for Inhibin Beta A (INHbA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV973Mu01 | Recombinant Inhibin Beta A (INHbA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV973Mu01 | Monoclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IP. |
| PAV973Mu01 | Polyclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV973Mu01 | CLIA Kit for Inhibin Beta A (INHbA) | CLIA assay for Antigen Detection |
| ELV973Mu01 | ELISA Kit for Inhibin Beta A (INHbA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV973Ra01 | Recombinant Inhibin Beta A (INHbA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV973Ra01 | Monoclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IP. |
| PAV973Ra01 | Polyclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV973Ra01 | CLIA Kit for Inhibin Beta A (INHbA) | CLIA assay for Antigen Detection |
| ELV973Ra01 | ELISA Kit for Inhibin Beta A (INHbA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV973Ca01 | Recombinant Inhibin Beta A (INHbA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV973Ca01 | Monoclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IP. |
| PAV973Ca01 | Polyclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV973Ca01 | CLIA Kit for Inhibin Beta A (INHbA) | CLIA assay for Antigen Detection |
| ELV973Ca01 | ELISA Kit for Inhibin Beta A (INHbA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV973Po01 | Recombinant Inhibin Beta A (INHbA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV973Po01 | Monoclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IP. |
| PAV973Po01 | Polyclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV973Po01 | CLIA Kit for Inhibin Beta A (INHbA) | CLIA assay for Antigen Detection |
| ELV973Po01 | ELISA Kit for Inhibin Beta A (INHbA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV973Bo01 | Recombinant Inhibin Beta A (INHbA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV973Bo01 | Monoclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IP. |
| PAV973Bo01 | Polyclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV973Bo01 | CLIA Kit for Inhibin Beta A (INHbA) | CLIA assay for Antigen Detection |
| ELV973Bo01 | ELISA Kit for Inhibin Beta A (INHbA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV973Rb01 | Recombinant Inhibin Beta A (INHbA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV973Rb01 | Monoclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IP. |
| PAV973Rb01 | Polyclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV973Rb01 | CLIA Kit for Inhibin Beta A (INHbA) | CLIA assay for Antigen Detection |
| ELV973Rb01 | ELISA Kit for Inhibin Beta A (INHbA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV973Mo01 | Recombinant Inhibin Beta A (INHbA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV973Mo01 | Monoclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IP. |
| PAV973Mo01 | Polyclonal Antibody to Inhibin Beta A (INHbA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV973Mo01 | CLIA Kit for Inhibin Beta A (INHbA) | CLIA assay for Antigen Detection |
| ELV973Mo01 | ELISA Kit for Inhibin Beta A (INHbA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Structure of two human ovarian inhibins."
Biochem. Biophys. Res. Commun. 135:957-964(1986) [PubMed] [Europe PMC] [Abstract]
"Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain."
Proc. Natl. Acad. Sci. U.S.A. 85:2434-2438(1988) [PubMed] [Europe PMC] [Abstract]
"Structure and sequence analysis of the human activin beta A subunit gene."
DNA Seq. 2:103-110(1991) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Human inhibin genes. Genomic characterisation and sequencing."
FEBS Lett. 206:329-334(1986) [PubMed] [Europe PMC] [Abstract]
"Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG)."
Endocrinology 144:1671-1674(2003) [PubMed] [Europe PMC] [Abstract]
"Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions."
EMBO J. 22:1555-1566(2003) [PubMed] [Europe PMC] [Abstract]
"The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity."
J. Biol. Chem. 283:32831-32838(2008) [PubMed] [Europe PMC] [Abstract]
"Germline mutations of inhibins in early-onset ovarian epithelial tumors."
Hum. Mutat. 35:294-297(2014) [PubMed] [Europe PMC] [Abstract]