Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL)
CD254; TNFSF11; ODF; OPGL; TRANCE; HRANKL2; SOdf; Tumor Necrosis Factor(ligand)superfamily Member 11; TNF-related activation-induced cytokine
RANKL a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV956Hu01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV956Hu01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IP. |
| PAV956Hu01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV956Hu01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | CLIA assay for Antigen Detection |
| ELV956Hu01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV956Mu01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV956Mu01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IP. |
| PAV956Mu01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV956Mu01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | CLIA assay for Antigen Detection |
| ELV956Mu01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV956Ra01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV956Ra01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IP. |
| PAV956Ra01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV956Ra01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | CLIA assay for Antigen Detection |
| ELV956Ra01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV956Ca01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV956Ca01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IP. |
| PAV956Ca01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV956Ca01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | CLIA assay for Antigen Detection |
| ELV956Ca01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV956Po01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV956Po01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IP. |
| PAV956Po01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV956Po01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | CLIA assay for Antigen Detection |
| ELV956Po01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV956Bo01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV956Bo01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IP. |
| PAV956Bo01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV956Bo01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | CLIA assay for Antigen Detection |
| ELV956Bo01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV956Rb01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV956Rb01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IP. |
| PAV956Rb01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV956Rb01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | CLIA assay for Antigen Detection |
| ELV956Rb01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV956Mo01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV956Mo01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IP. |
| PAV956Mo01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV956Mo01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | CLIA assay for Antigen Detection |
| ELV956Mo01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function."
Nature 390:175-179(1997) [PubMed] [Europe PMC] [Abstract]
"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation."
Cell 93:165-176(1998) [PubMed] [Europe PMC] [Abstract]
"Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation."
Biochem. Biophys. Res. Commun. 269:532-536(2000) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells."
J. Biol. Chem. 272:25190-25194(1997) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin."
J. Immunol. 189:245-252(2012) [PubMed] [Europe PMC] [Abstract]
"Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL."
Nat. Genet. 39:960-962(2007) [PubMed] [Europe PMC] [Abstract]