Neuropeptide Y (NPY)
NP-Y; PYY4; CPON; Pro-neuropeptide Y; Neuropeptide tyrosine; C-flanking peptide of NPY
Neuropeptide Y (NPY) is a 36 amino acid peptide neurotransmitter found in the brain and autonomic nervous system.NPY is a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV932Hu01 | Recombinant Neuropeptide Y (NPY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV932Hu01 | Monoclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IP. |
| PAV932Hu01 | Polyclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV932Hu01 | CLIA Kit for Neuropeptide Y (NPY) | CLIA assay for Antigen Detection |
| ELV932Hu01 | ELISA Kit for Neuropeptide Y (NPY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV932Mu01 | Recombinant Neuropeptide Y (NPY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV932Mu01 | Monoclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IP. |
| PAV932Mu01 | Polyclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV932Mu01 | CLIA Kit for Neuropeptide Y (NPY) | CLIA assay for Antigen Detection |
| ELV932Mu01 | ELISA Kit for Neuropeptide Y (NPY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV932Ra01 | Recombinant Neuropeptide Y (NPY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV932Ra01 | Monoclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IP. |
| PAV932Ra01 | Polyclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV932Ra01 | CLIA Kit for Neuropeptide Y (NPY) | CLIA assay for Antigen Detection |
| ELV932Ra01 | ELISA Kit for Neuropeptide Y (NPY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV932Ca01 | Recombinant Neuropeptide Y (NPY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV932Ca01 | Monoclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IP. |
| PAV932Ca01 | Polyclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV932Ca01 | CLIA Kit for Neuropeptide Y (NPY) | CLIA assay for Antigen Detection |
| ELV932Ca01 | ELISA Kit for Neuropeptide Y (NPY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV932Po01 | Recombinant Neuropeptide Y (NPY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV932Po01 | Monoclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IP. |
| PAV932Po01 | Polyclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV932Po01 | CLIA Kit for Neuropeptide Y (NPY) | CLIA assay for Antigen Detection |
| ELV932Po01 | ELISA Kit for Neuropeptide Y (NPY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV932Bo01 | Recombinant Neuropeptide Y (NPY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV932Bo01 | Monoclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IP. |
| PAV932Bo01 | Polyclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV932Bo01 | CLIA Kit for Neuropeptide Y (NPY) | CLIA assay for Antigen Detection |
| ELV932Bo01 | ELISA Kit for Neuropeptide Y (NPY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV932Rb01 | Recombinant Neuropeptide Y (NPY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV932Rb01 | Monoclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IP. |
| PAV932Rb01 | Polyclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV932Rb01 | CLIA Kit for Neuropeptide Y (NPY) | CLIA assay for Antigen Detection |
| ELV932Rb01 | ELISA Kit for Neuropeptide Y (NPY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV932Mo01 | Recombinant Neuropeptide Y (NPY) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV932Mo01 | Monoclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IP. |
| PAV932Mo01 | Polyclonal Antibody to Neuropeptide Y (NPY) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV932Mo01 | CLIA Kit for Neuropeptide Y (NPY) | CLIA assay for Antigen Detection |
| ELV932Mo01 | ELISA Kit for Neuropeptide Y (NPY) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine."
Proc. Natl. Acad. Sci. U.S.A. 81:4577-4581(1984) [PubMed] [Europe PMC] [Abstract]
"Characterization, sequence, and expression of the cloned human neuropeptide Y gene."
J. Biol. Chem. 261:11974-11979(1986) [PubMed] [Europe PMC] [Abstract]
"Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7."
J. Clin. Invest. 77:1038-1041(1986) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Presence of the predicted C-flanking peptide of neuropeptide Y (CPON) in tissue extracts."
Neuropeptides 6:95-100(1985) [PubMed] [Europe PMC] [Abstract]
"Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha."
FEBS J. 278:1316-1332(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Solution conformation of human neuropeptide Y by 1H nuclear magnetic resonance and restrained molecular dynamics."
Eur. J. Biochem. 209:765-771(1992) [PubMed] [Europe PMC] [Abstract]
"Solution structure of human neuropeptide Y."
J. Biomol. NMR 8:379-390(1996) [PubMed] [Europe PMC] [Abstract]
"Helical structure and self-association in a 13 residue neuropeptide Y Y2 receptor agonist: relationship to biological activity."
Biochim. Biophys. Acta 1435:127-137(1999) [PubMed] [Europe PMC] [Abstract]