Cystatin 3 (CST3)
Cys-C; Cystatin C; Gamma Trace; Post-Gamma-Globulin; Neuroendocrine Basic Polypeptide; Amyloid Angiopathy And Cerebral Hemorrhage
Cystatin C: A serum protein that is filtered out of the blood by the kidneys and that serves as a measure of kidney function. Cystatin C is produced steadily by all types of nucleated cells in the body. Its low molecular mass allows it to be freely filtered by the glomerular membrane in the kidney.
Its concentration in blood correlates with the glomerular filtration rate. The levels of cystatin C are independent of weight and height, muscle mass, age (over a year of age), and sex. Measurements can be made and interpreted from a single random sample. Cystatin C is a better marker of the glomerular filtration rate and hence of kidney function than creatinine which was the most commonly used measure of kidney function.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV915Hu01 | Recombinant Cystatin 3 (CST3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV915Hu01 | Monoclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IP. |
| PAV915Hu01 | Polyclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV915Hu01 | CLIA Kit for Cystatin 3 (CST3) | CLIA assay for Antigen Detection |
| ELV915Hu01 | ELISA Kit for Cystatin 3 (CST3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV915Mu01 | Recombinant Cystatin 3 (CST3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV915Mu01 | Monoclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IP. |
| PAV915Mu01 | Polyclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV915Mu01 | CLIA Kit for Cystatin 3 (CST3) | CLIA assay for Antigen Detection |
| ELV915Mu01 | ELISA Kit for Cystatin 3 (CST3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV915Ra01 | Recombinant Cystatin 3 (CST3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV915Ra01 | Monoclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IP. |
| PAV915Ra01 | Polyclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV915Ra01 | CLIA Kit for Cystatin 3 (CST3) | CLIA assay for Antigen Detection |
| ELV915Ra01 | ELISA Kit for Cystatin 3 (CST3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV915Ca01 | Recombinant Cystatin 3 (CST3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV915Ca01 | Monoclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IP. |
| PAV915Ca01 | Polyclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV915Ca01 | CLIA Kit for Cystatin 3 (CST3) | CLIA assay for Antigen Detection |
| ELV915Ca01 | ELISA Kit for Cystatin 3 (CST3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV915Po01 | Recombinant Cystatin 3 (CST3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV915Po01 | Monoclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IP. |
| PAV915Po01 | Polyclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV915Po01 | CLIA Kit for Cystatin 3 (CST3) | CLIA assay for Antigen Detection |
| ELV915Po01 | ELISA Kit for Cystatin 3 (CST3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV915Bo01 | Recombinant Cystatin 3 (CST3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV915Bo01 | Monoclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IP. |
| PAV915Bo01 | Polyclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV915Bo01 | CLIA Kit for Cystatin 3 (CST3) | CLIA assay for Antigen Detection |
| ELV915Bo01 | ELISA Kit for Cystatin 3 (CST3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV915Rb01 | Recombinant Cystatin 3 (CST3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV915Rb01 | Monoclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IP. |
| PAV915Rb01 | Polyclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV915Rb01 | CLIA Kit for Cystatin 3 (CST3) | CLIA assay for Antigen Detection |
| ELV915Rb01 | ELISA Kit for Cystatin 3 (CST3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV915Mo01 | Recombinant Cystatin 3 (CST3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV915Mo01 | Monoclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IP. |
| PAV915Mo01 | Polyclonal Antibody to Cystatin 3 (CST3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV915Mo01 | CLIA Kit for Cystatin 3 (CST3) | CLIA assay for Antigen Detection |
| ELV915Mo01 | ELISA Kit for Cystatin 3 (CST3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C."
FEBS Lett. 216:229-233(1987) [PubMed] [Europe PMC] [Abstract]
"The human cystatin C gene (CST3) is a member of the cystatin gene family which is localized on chromosome 20."
Biochem. Biophys. Res. Commun. 162:1324-1331(1989) [PubMed] [Europe PMC] [Abstract]
"Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases."
J. Exp. Med. 169:1771-1778(1989) [PubMed] [Europe PMC] [Abstract]
"Structure and expression of the human cystatin C gene."
Biochem. J. 268:287-294(1990) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis."
Proc. Natl. Acad. Sci. U.S.A. 79:3024-3027(1982) [PubMed] [Europe PMC] [Abstract]
"Human cystatin, a new protein inhibitor of cysteine proteinases."
Biochem. Biophys. Res. Commun. 118:103-109(1984) [PubMed] [Europe PMC] [Abstract]
"Protein inhibitors of cysteine proteinases. III. Amino-acid sequence of cystatin from chicken egg white."
Hoppe-Seyler's Z. Physiol. Chem. 364:1487-1496(1983) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"The disulphide bridges of human cystatin C (gamma-trace) and chicken cystatin."
FEBS Lett. 170:370-374(1984)
"Cystatin C as a potential cerebrospinal fluid marker for the diagnosis of Creutzfeldt-Jakob disease."
Proteomics 4:2229-2233(2004) [PubMed] [Europe PMC] [Abstract]
"A dual Golgi- and mitochondria-localised Ala25Ser precursor cystatin C: an additional tool for characterising intracellular mis-localisation leading to increased AMD susceptibility."
Exp. Eye Res. 84:1135-1139(2007) [PubMed] [Europe PMC] [Abstract]
"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
"Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry."
J. Am. Soc. Mass Spectrom. 21:908-917(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Resveratrol-induced changes of the human adipocyte secretion profile."
J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
"Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping."
Nat. Struct. Biol. 8:316-320(2001) [PubMed] [Europe PMC] [Abstract]
"3D domain-swapped human cystatin C with amyloid-like intermolecular beta-sheets."
Proteins 61:570-578(2005) [PubMed] [Europe PMC] [Abstract]
"Hereditary cystatin C amyloid angiopathy: identification of the disease-causing mutation and specific diagnosis by polymerase chain reaction based analysis."
Hum. Genet. 89:377-380(1992) [PubMed] [Europe PMC] [Abstract]
"CST3 genotype associated with exudative age related macular degeneration."
Br. J. Ophthalmol. 86:214-219(2002) [PubMed] [Europe PMC] [Abstract]