Chemokine C-C-Motif Receptor 2 (CCR2)
CD192; CC-CKR2; CCR2A; C-C CKR-2; CCR2B; CKR2-A; CKR2-B; CMKBR2; MCP1-R; Monocyte chemoattractant protein 1 receptor
CCR2, short for chemokine (C-C motif) receptor 2, is a chemokine receptor. CCR2 has also recently been designated CD192 . This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis.
Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV897Hu01 | Recombinant Chemokine C-C-Motif Receptor 2 (CCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV897Hu01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IP. |
| PAV897Hu01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV897Hu01 | CLIA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | CLIA assay for Antigen Detection |
| ELV897Hu01 | ELISA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV897Mu01 | Recombinant Chemokine C-C-Motif Receptor 2 (CCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV897Mu01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IP. |
| PAV897Mu01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV897Mu01 | CLIA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | CLIA assay for Antigen Detection |
| ELV897Mu01 | ELISA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV897Ra01 | Recombinant Chemokine C-C-Motif Receptor 2 (CCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV897Ra01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IP. |
| PAV897Ra01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV897Ra01 | CLIA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | CLIA assay for Antigen Detection |
| ELV897Ra01 | ELISA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV897Ca01 | Recombinant Chemokine C-C-Motif Receptor 2 (CCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV897Ca01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IP. |
| PAV897Ca01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV897Ca01 | CLIA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | CLIA assay for Antigen Detection |
| ELV897Ca01 | ELISA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV897Po01 | Recombinant Chemokine C-C-Motif Receptor 2 (CCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV897Po01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IP. |
| PAV897Po01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV897Po01 | CLIA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | CLIA assay for Antigen Detection |
| ELV897Po01 | ELISA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV897Bo01 | Recombinant Chemokine C-C-Motif Receptor 2 (CCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV897Bo01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IP. |
| PAV897Bo01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV897Bo01 | CLIA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | CLIA assay for Antigen Detection |
| ELV897Bo01 | ELISA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV897Rb01 | Recombinant Chemokine C-C-Motif Receptor 2 (CCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV897Rb01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IP. |
| PAV897Rb01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV897Rb01 | CLIA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | CLIA assay for Antigen Detection |
| ELV897Rb01 | ELISA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV897Mo01 | Recombinant Chemokine C-C-Motif Receptor 2 (CCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV897Mo01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IP. |
| PAV897Mo01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 2 (CCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV897Mo01 | CLIA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | CLIA assay for Antigen Detection |
| ELV897Mo01 | ELISA Kit for Chemokine C-C-Motif Receptor 2 (CCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails."
Proc. Natl. Acad. Sci. U.S.A. 91:2752-2756(1994) [PubMed] [Europe PMC] [Abstract]
"cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor."
Biochem. Biophys. Res. Commun. 202:1156-1162(1994) [PubMed] [Europe PMC] [Abstract]
"Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking."
J. Biol. Chem. 272:1038-1045(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor."
J. Immunol. 161:805-813(1998) [PubMed] [Europe PMC] [Abstract]
"Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2."
Proc. Natl. Acad. Sci. U.S.A. 95:2985-2990(1998) [PubMed] [Europe PMC] [Abstract]
"HIV-1 Tat protein mimicry of chemokines."
Proc. Natl. Acad. Sci. U.S.A. 95:13153-13158(1998) [PubMed] [Europe PMC] [Abstract]
"Monocyte chemotactic protein-1 receptor CCR2B is a glycoprotein that has tyrosine sulfation in a conserved extracellular N-terminal region."
J. Immunol. 165:5295-5303(2000) [PubMed] [Europe PMC] [Abstract]
"Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration."
Exp. Mol. Med. 40:332-338(2008) [PubMed] [Europe PMC] [Abstract]
"Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1)."
J. Biol. Chem. 288:10024-10034(2013) [PubMed] [Europe PMC] [Abstract]
"Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression."
Science 277:959-965(1997) [PubMed] [Europe PMC] [Abstract]
"Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression."
Nat. Med. 4:786-793(1998) [PubMed] [Europe PMC] [Abstract]