Protein Interacting With Protein Kinase C Alpha 1 (PICK1)
PRKCABP; Protein kinase C,Alpha Binding Protein; Protein interacting with C kinase 1; Protein kinase C-alpha-binding protein
PRKCA-binding protein is a protein contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function.
This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV880Hu01 | Recombinant Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV880Hu01 | Monoclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IP. |
| PAV880Hu01 | Polyclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV880Hu01 | CLIA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | CLIA assay for Antigen Detection |
| ELV880Hu01 | ELISA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV880Mu01 | Recombinant Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV880Mu01 | Monoclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IP. |
| PAV880Mu01 | Polyclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV880Mu01 | CLIA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | CLIA assay for Antigen Detection |
| ELV880Mu01 | ELISA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV880Ra01 | Recombinant Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV880Ra01 | Monoclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IP. |
| PAV880Ra01 | Polyclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV880Ra01 | CLIA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | CLIA assay for Antigen Detection |
| ELV880Ra01 | ELISA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV880Ca01 | Recombinant Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV880Ca01 | Monoclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IP. |
| PAV880Ca01 | Polyclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV880Ca01 | CLIA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | CLIA assay for Antigen Detection |
| ELV880Ca01 | ELISA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV880Po01 | Recombinant Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV880Po01 | Monoclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IP. |
| PAV880Po01 | Polyclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV880Po01 | CLIA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | CLIA assay for Antigen Detection |
| ELV880Po01 | ELISA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV880Bo01 | Recombinant Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV880Bo01 | Monoclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IP. |
| PAV880Bo01 | Polyclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV880Bo01 | CLIA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | CLIA assay for Antigen Detection |
| ELV880Bo01 | ELISA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV880Rb01 | Recombinant Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV880Rb01 | Monoclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IP. |
| PAV880Rb01 | Polyclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV880Rb01 | CLIA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | CLIA assay for Antigen Detection |
| ELV880Rb01 | ELISA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV880Mo01 | Recombinant Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV880Mo01 | Monoclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IP. |
| PAV880Mo01 | Polyclonal Antibody to Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV880Mo01 | CLIA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | CLIA assay for Antigen Detection |
| ELV880Mo01 | ELISA Kit for Protein Interacting With Protein Kinase C Alpha 1 (PICK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors."
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering."
Mol. Pharmacol. 60:916-923(2001) [PubMed] [Europe PMC] [Abstract]
"Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1."
Neuron 30:121-134(2001) [PubMed] [Europe PMC] [Abstract]
"Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)."
Biochem. J. 361:443-450(2002) [PubMed] [Europe PMC] [Abstract]
"A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth."
J. Cell Sci. 117:4401-4409(2004) [PubMed] [Europe PMC] [Abstract]
"The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands."
J. Biol. Chem. 279:41393-41397(2004) [PubMed] [Europe PMC] [Abstract]
"Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization."
Neurochem. Int. 56:962-970(2010) [PubMed] [Europe PMC] [Abstract]
"Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions."
Protein Sci. 16:683-694(2007) [PubMed] [Europe PMC] [Abstract]