Signal Regulatory Protein Gamma (SIRPg)
CD172g; CD172-G; SIRP-G; SIRP-B2; SIRPB2; SIRP-b2; SIRP-beta-2; SIRPgamma; CD172 antigen-like family member B; Signal-regulatory protein beta-2
Signal-regulatory protein gamma is a protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.
The 354-amino acid protein shares approximately 75% sequence identity with SIRPB1. It possesses a putative signal sequence, a long extracellular domain, a transmembrane region, a short intracellular domain, and no catalytic domain. RT-PCR analysis detected expression of SIRPG at varying levels in all tissues tested.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV864Hu01 | Recombinant Signal Regulatory Protein Gamma (SIRPg) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV864Hu01 | Monoclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IP. |
| PAV864Hu01 | Polyclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV864Hu01 | CLIA Kit for Signal Regulatory Protein Gamma (SIRPg) | CLIA assay for Antigen Detection |
| ELV864Hu01 | ELISA Kit for Signal Regulatory Protein Gamma (SIRPg) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV864Mu01 | Recombinant Signal Regulatory Protein Gamma (SIRPg) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV864Mu01 | Monoclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IP. |
| PAV864Mu01 | Polyclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV864Mu01 | CLIA Kit for Signal Regulatory Protein Gamma (SIRPg) | CLIA assay for Antigen Detection |
| ELV864Mu01 | ELISA Kit for Signal Regulatory Protein Gamma (SIRPg) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV864Ra01 | Recombinant Signal Regulatory Protein Gamma (SIRPg) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV864Ra01 | Monoclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IP. |
| PAV864Ra01 | Polyclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV864Ra01 | CLIA Kit for Signal Regulatory Protein Gamma (SIRPg) | CLIA assay for Antigen Detection |
| ELV864Ra01 | ELISA Kit for Signal Regulatory Protein Gamma (SIRPg) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV864Ca01 | Recombinant Signal Regulatory Protein Gamma (SIRPg) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV864Ca01 | Monoclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IP. |
| PAV864Ca01 | Polyclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV864Ca01 | CLIA Kit for Signal Regulatory Protein Gamma (SIRPg) | CLIA assay for Antigen Detection |
| ELV864Ca01 | ELISA Kit for Signal Regulatory Protein Gamma (SIRPg) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV864Po01 | Recombinant Signal Regulatory Protein Gamma (SIRPg) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV864Po01 | Monoclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IP. |
| PAV864Po01 | Polyclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV864Po01 | CLIA Kit for Signal Regulatory Protein Gamma (SIRPg) | CLIA assay for Antigen Detection |
| ELV864Po01 | ELISA Kit for Signal Regulatory Protein Gamma (SIRPg) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV864Bo01 | Recombinant Signal Regulatory Protein Gamma (SIRPg) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV864Bo01 | Monoclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IP. |
| PAV864Bo01 | Polyclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV864Bo01 | CLIA Kit for Signal Regulatory Protein Gamma (SIRPg) | CLIA assay for Antigen Detection |
| ELV864Bo01 | ELISA Kit for Signal Regulatory Protein Gamma (SIRPg) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV864Rb01 | Recombinant Signal Regulatory Protein Gamma (SIRPg) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV864Rb01 | Monoclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IP. |
| PAV864Rb01 | Polyclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV864Rb01 | CLIA Kit for Signal Regulatory Protein Gamma (SIRPg) | CLIA assay for Antigen Detection |
| ELV864Rb01 | ELISA Kit for Signal Regulatory Protein Gamma (SIRPg) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV864Mo01 | Recombinant Signal Regulatory Protein Gamma (SIRPg) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV864Mo01 | Monoclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IP. |
| PAV864Mo01 | Polyclonal Antibody to Signal Regulatory Protein Gamma (SIRPg) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV864Mo01 | CLIA Kit for Signal Regulatory Protein Gamma (SIRPg) | CLIA assay for Antigen Detection |
| ELV864Mo01 | ELISA Kit for Signal Regulatory Protein Gamma (SIRPg) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family."
J. Hum. Genet. 45:378-382(2000) [PubMed] [Europe PMC] [Abstract]
"Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation."
Blood 105:2421-2427(2005) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
"Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47."
Mol. Cell 31:266-277(2008) [PubMed] [Europe PMC] [Abstract]