Thymidine Phosphorylase (TP)
TYMP; PDECGF; ECGF1; MNGIE; TP; HPD-ECGF; TdRPase; Platelet-Derived Endothelial Cell Growth Factor; Gliostatin
Platelet-derived endothelial cell growth factor is a novel angiogenic factor distinct from the previously described endothelial cell mitogens of the fibroblast growth factor family. PD-ECGF, which is stored in platelets as a 45-kD single polypeptide chain, has a highly restricted target cell specificity acting only on endothelial cells. It promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells.
Cloning of the gene revealed that it contains 10 exons spanning more than 4.3 kb .Using an ECGF1 cDNA probe, Stenman et al. assigned the ECGF1 gene to chromosome 22 by analysis of its segregation in a panel of human/rodent somatic cell hybrids. By in situ hybridization, they sublocalized the gene to 22q13.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV863Hu01 | Recombinant Thymidine Phosphorylase (TP) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV863Hu01 | Monoclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IP. |
PAV863Hu01 | Polyclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IF. | |
Assay Kits | CLV863Hu01 | CLIA Kit for Thymidine Phosphorylase (TP) | CLIA assay for Antigen Detection |
ELV863Hu01 | ELISA Kit for Thymidine Phosphorylase (TP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV863Mu01 | Recombinant Thymidine Phosphorylase (TP) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV863Mu01 | Monoclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IP. |
PAV863Mu01 | Polyclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IF. | |
Assay Kits | CLV863Mu01 | CLIA Kit for Thymidine Phosphorylase (TP) | CLIA assay for Antigen Detection |
ELV863Mu01 | ELISA Kit for Thymidine Phosphorylase (TP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV863Ra01 | Recombinant Thymidine Phosphorylase (TP) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV863Ra01 | Monoclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IP. |
PAV863Ra01 | Polyclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IF. | |
Assay Kits | CLV863Ra01 | CLIA Kit for Thymidine Phosphorylase (TP) | CLIA assay for Antigen Detection |
ELV863Ra01 | ELISA Kit for Thymidine Phosphorylase (TP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV863Ca01 | Recombinant Thymidine Phosphorylase (TP) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV863Ca01 | Monoclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IP. |
PAV863Ca01 | Polyclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IF. | |
Assay Kits | CLV863Ca01 | CLIA Kit for Thymidine Phosphorylase (TP) | CLIA assay for Antigen Detection |
ELV863Ca01 | ELISA Kit for Thymidine Phosphorylase (TP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV863Po01 | Recombinant Thymidine Phosphorylase (TP) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV863Po01 | Monoclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IP. |
PAV863Po01 | Polyclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IF. | |
Assay Kits | CLV863Po01 | CLIA Kit for Thymidine Phosphorylase (TP) | CLIA assay for Antigen Detection |
ELV863Po01 | ELISA Kit for Thymidine Phosphorylase (TP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV863Bo01 | Recombinant Thymidine Phosphorylase (TP) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV863Bo01 | Monoclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IP. |
PAV863Bo01 | Polyclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IF. | |
Assay Kits | CLV863Bo01 | CLIA Kit for Thymidine Phosphorylase (TP) | CLIA assay for Antigen Detection |
ELV863Bo01 | ELISA Kit for Thymidine Phosphorylase (TP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV863Rb01 | Recombinant Thymidine Phosphorylase (TP) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV863Rb01 | Monoclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IP. |
PAV863Rb01 | Polyclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IF. | |
Assay Kits | CLV863Rb01 | CLIA Kit for Thymidine Phosphorylase (TP) | CLIA assay for Antigen Detection |
ELV863Rb01 | ELISA Kit for Thymidine Phosphorylase (TP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPV863Mo01 | Recombinant Thymidine Phosphorylase (TP) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAV863Mo01 | Monoclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IP. |
PAV863Mo01 | Polyclonal Antibody to Thymidine Phosphorylase (TP) | WB; IHC; ICC; IF. | |
Assay Kits | CLV863Mo01 | CLIA Kit for Thymidine Phosphorylase (TP) | CLIA assay for Antigen Detection |
ELV863Mo01 | ELISA Kit for Thymidine Phosphorylase (TP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Nature 338:557-562(1989) [PubMed] [Europe PMC] [Abstract]
"Expression of recombinant platelet-derived endothelial cell growth factor in the yeast Saccharomyces cerevisiae."
Yeast 8:57-60(1992) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
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Nature 356:668-668(1992) [PubMed] [Europe PMC] [Abstract]
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"Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity."
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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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Biochem. J. 399:199-204(2006) [PubMed] [Europe PMC] [Abstract]
"Structures of native human thymidine phosphorylase and in complex with 5-iodouracil."
Biochem. Biophys. Res. Commun. 386:666-670(2009) [PubMed] [Europe PMC] [Abstract]
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Science 283:689-692(1999) [PubMed] [Europe PMC] [Abstract]
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Neurology 59:455-457(2002) [PubMed] [Europe PMC] [Abstract]