Heat Shock Transcription Factor 4 (HSF4)
CTM; Heat Shock Factor Protein 4; Cataract,Marner
HSF4 is a novel member of the HSF family, rather than the human homolog of chicken HSF3. They reported that the HSF4 sequence encodes a 463-amino acid polypeptide. Northern blotting revealed that HSF4 is expressed as a 2.5-kb mRNA in the heart, skeletal muscle, and brain, and at much lower levels in some other tissues. HSF4 bound specifically to the heat-shock response element but repressed, rather than activated, transcription.
HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV860Hu01 | Recombinant Heat Shock Transcription Factor 4 (HSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV860Hu01 | Monoclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IP. |
| PAV860Hu01 | Polyclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV860Hu01 | CLIA Kit for Heat Shock Transcription Factor 4 (HSF4) | CLIA assay for Antigen Detection |
| ELV860Hu01 | ELISA Kit for Heat Shock Transcription Factor 4 (HSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV860Mu01 | Recombinant Heat Shock Transcription Factor 4 (HSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV860Mu01 | Monoclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IP. |
| PAV860Mu01 | Polyclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV860Mu01 | CLIA Kit for Heat Shock Transcription Factor 4 (HSF4) | CLIA assay for Antigen Detection |
| ELV860Mu01 | ELISA Kit for Heat Shock Transcription Factor 4 (HSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV860Ra01 | Recombinant Heat Shock Transcription Factor 4 (HSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV860Ra01 | Monoclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IP. |
| PAV860Ra01 | Polyclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV860Ra01 | CLIA Kit for Heat Shock Transcription Factor 4 (HSF4) | CLIA assay for Antigen Detection |
| ELV860Ra01 | ELISA Kit for Heat Shock Transcription Factor 4 (HSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV860Ca01 | Recombinant Heat Shock Transcription Factor 4 (HSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV860Ca01 | Monoclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IP. |
| PAV860Ca01 | Polyclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV860Ca01 | CLIA Kit for Heat Shock Transcription Factor 4 (HSF4) | CLIA assay for Antigen Detection |
| ELV860Ca01 | ELISA Kit for Heat Shock Transcription Factor 4 (HSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV860Po01 | Recombinant Heat Shock Transcription Factor 4 (HSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV860Po01 | Monoclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IP. |
| PAV860Po01 | Polyclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV860Po01 | CLIA Kit for Heat Shock Transcription Factor 4 (HSF4) | CLIA assay for Antigen Detection |
| ELV860Po01 | ELISA Kit for Heat Shock Transcription Factor 4 (HSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV860Bo01 | Recombinant Heat Shock Transcription Factor 4 (HSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV860Bo01 | Monoclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IP. |
| PAV860Bo01 | Polyclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV860Bo01 | CLIA Kit for Heat Shock Transcription Factor 4 (HSF4) | CLIA assay for Antigen Detection |
| ELV860Bo01 | ELISA Kit for Heat Shock Transcription Factor 4 (HSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV860Rb01 | Recombinant Heat Shock Transcription Factor 4 (HSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV860Rb01 | Monoclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IP. |
| PAV860Rb01 | Polyclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV860Rb01 | CLIA Kit for Heat Shock Transcription Factor 4 (HSF4) | CLIA assay for Antigen Detection |
| ELV860Rb01 | ELISA Kit for Heat Shock Transcription Factor 4 (HSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV860Mo01 | Recombinant Heat Shock Transcription Factor 4 (HSF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV860Mo01 | Monoclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IP. |
| PAV860Mo01 | Polyclonal Antibody to Heat Shock Transcription Factor 4 (HSF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV860Mo01 | CLIA Kit for Heat Shock Transcription Factor 4 (HSF4) | CLIA assay for Antigen Detection |
| ELV860Mo01 | ELISA Kit for Heat Shock Transcription Factor 4 (HSF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator."
Mol. Cell. Biol. 17:469-481(1997) [PubMed] [Europe PMC] [Abstract]
"The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing."
J. Biol. Chem. 274:27845-27856(1999) [PubMed] [Europe PMC] [Abstract]
"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
"Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26."
Mol. Cell. Biol. 26:3282-3294(2006) [PubMed] [Europe PMC] [Abstract]
"PDSM, a motif for phosphorylation-dependent SUMO modification."
Proc. Natl. Acad. Sci. U.S.A. 103:45-50(2006) [PubMed] [Europe PMC] [Abstract]
"Human ALKBH4 interacts with proteins associated with transcription."
PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
"Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract."
Nat. Genet. 31:276-278(2002) [PubMed] [Europe PMC] [Abstract]
"Novel HSF4 mutation causes congenital total white cataract in a Chinese family."
Am. J. Ophthalmol. 142:298-303(2006) [PubMed] [Europe PMC] [Abstract]