Cluster Of Differentiation 6 (CD6)
TP120; T12; T-cell differentiation antigen CD6
CD6 is a monomeric 105- or 130-kD membrane glycoprotein that is involved in T-cell activation. The size difference between the 2 CD6 forms is due to differences in phosphorylation .
By screening a human peripheral blood acute lymphocytic leukemia cell cDNA expression library with antibodies against CD6, Aruffo et al. (1991) cloned a cDNA encoding CD6. The predicted 468-amino acid protein contains a 24-amino acid signal sequence, 3 extracellular 'scavenger receptor cysteine-rich' (SRCR) domains, a membrane-spanning domain, and a 44-amino acid cytoplasmic domain. It shows significant homology to CD5 . By Northern blot analysis, CD6 is expressed as an approximately 3-kb mRNA in T cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV859Hu01 | Recombinant Cluster Of Differentiation 6 (CD6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV859Hu01 | Monoclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IP. |
| PAV859Hu01 | Polyclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV859Hu01 | CLIA Kit for Cluster Of Differentiation 6 (CD6) | CLIA assay for Antigen Detection |
| ELV859Hu01 | ELISA Kit for Cluster Of Differentiation 6 (CD6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV859Mu01 | Recombinant Cluster Of Differentiation 6 (CD6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV859Mu01 | Monoclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IP. |
| PAV859Mu01 | Polyclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV859Mu01 | CLIA Kit for Cluster Of Differentiation 6 (CD6) | CLIA assay for Antigen Detection |
| ELV859Mu01 | ELISA Kit for Cluster Of Differentiation 6 (CD6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV859Ra01 | Recombinant Cluster Of Differentiation 6 (CD6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV859Ra01 | Monoclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IP. |
| PAV859Ra01 | Polyclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV859Ra01 | CLIA Kit for Cluster Of Differentiation 6 (CD6) | CLIA assay for Antigen Detection |
| ELV859Ra01 | ELISA Kit for Cluster Of Differentiation 6 (CD6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV859Ca01 | Recombinant Cluster Of Differentiation 6 (CD6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV859Ca01 | Monoclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IP. |
| PAV859Ca01 | Polyclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV859Ca01 | CLIA Kit for Cluster Of Differentiation 6 (CD6) | CLIA assay for Antigen Detection |
| ELV859Ca01 | ELISA Kit for Cluster Of Differentiation 6 (CD6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV859Po01 | Recombinant Cluster Of Differentiation 6 (CD6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV859Po01 | Monoclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IP. |
| PAV859Po01 | Polyclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV859Po01 | CLIA Kit for Cluster Of Differentiation 6 (CD6) | CLIA assay for Antigen Detection |
| ELV859Po01 | ELISA Kit for Cluster Of Differentiation 6 (CD6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV859Bo01 | Recombinant Cluster Of Differentiation 6 (CD6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV859Bo01 | Monoclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IP. |
| PAV859Bo01 | Polyclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV859Bo01 | CLIA Kit for Cluster Of Differentiation 6 (CD6) | CLIA assay for Antigen Detection |
| ELV859Bo01 | ELISA Kit for Cluster Of Differentiation 6 (CD6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV859Rb01 | Recombinant Cluster Of Differentiation 6 (CD6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV859Rb01 | Monoclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IP. |
| PAV859Rb01 | Polyclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV859Rb01 | CLIA Kit for Cluster Of Differentiation 6 (CD6) | CLIA assay for Antigen Detection |
| ELV859Rb01 | ELISA Kit for Cluster Of Differentiation 6 (CD6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV859Mo01 | Recombinant Cluster Of Differentiation 6 (CD6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV859Mo01 | Monoclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IP. |
| PAV859Mo01 | Polyclonal Antibody to Cluster Of Differentiation 6 (CD6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV859Mo01 | CLIA Kit for Cluster Of Differentiation 6 (CD6) | CLIA assay for Antigen Detection |
| ELV859Mo01 | ELISA Kit for Cluster Of Differentiation 6 (CD6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms."
J. Immunol. 158:1149-1156(1997) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
"The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins."
J. Exp. Med. 174:949-952(1991) [PubMed] [Europe PMC] [Abstract]
"Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse."
J. Immunol. 178:4351-4361(2007) [PubMed] [Europe PMC] [Abstract]
"Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule."
J. Biol. Chem. 266:7137-7143(1991) [PubMed] [Europe PMC] [Abstract]
"Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors."
J. Exp. Med. 177:219-223(1993) [PubMed] [Europe PMC] [Abstract]