Kallikrein 1 (KLK1)
KLKR; Klk6; HK1; Kallikrein 1,Renal/Pancreas/Salivary; Kidney/pancreas/salivary gland kallikrein; Tissue kallikrein
KLK1, or tissue kallikrein is a serine protease that generates Lys-bradykinin by specific proteolysis of kininogen-1. Kallikrein 1 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. the deduced 262-amino acid KLK1 protein contains a putative signal peptide, followed by a short activating peptide and the protease domain. The protease domain contains the catalytic triad of his65, asp120, and ser214. RT-PCR detected variable expression of KLK1 in most of the 35 tissues examined. Highest expression was in pancreas, salivary gland, thyroid, parotid gland, fetal and adult skin, kidney, and liver.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV845Hu01 | Recombinant Kallikrein 1 (KLK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV845Hu01 | Monoclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IP. |
| PAV845Hu01 | Polyclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV845Hu01 | CLIA Kit for Kallikrein 1 (KLK1) | CLIA assay for Antigen Detection |
| ELV845Hu01 | ELISA Kit for Kallikrein 1 (KLK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV845Mu01 | Recombinant Kallikrein 1 (KLK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV845Mu01 | Monoclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IP. |
| PAV845Mu01 | Polyclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV845Mu01 | CLIA Kit for Kallikrein 1 (KLK1) | CLIA assay for Antigen Detection |
| ELV845Mu01 | ELISA Kit for Kallikrein 1 (KLK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV845Ra01 | Recombinant Kallikrein 1 (KLK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV845Ra01 | Monoclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IP. |
| PAV845Ra01 | Polyclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV845Ra01 | CLIA Kit for Kallikrein 1 (KLK1) | CLIA assay for Antigen Detection |
| ELV845Ra01 | ELISA Kit for Kallikrein 1 (KLK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV845Ca01 | Recombinant Kallikrein 1 (KLK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV845Ca01 | Monoclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IP. |
| PAV845Ca01 | Polyclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV845Ca01 | CLIA Kit for Kallikrein 1 (KLK1) | CLIA assay for Antigen Detection |
| ELV845Ca01 | ELISA Kit for Kallikrein 1 (KLK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV845Po01 | Recombinant Kallikrein 1 (KLK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV845Po01 | Monoclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IP. |
| PAV845Po01 | Polyclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV845Po01 | CLIA Kit for Kallikrein 1 (KLK1) | CLIA assay for Antigen Detection |
| ELV845Po01 | ELISA Kit for Kallikrein 1 (KLK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV845Bo01 | Recombinant Kallikrein 1 (KLK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV845Bo01 | Monoclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IP. |
| PAV845Bo01 | Polyclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV845Bo01 | CLIA Kit for Kallikrein 1 (KLK1) | CLIA assay for Antigen Detection |
| ELV845Bo01 | ELISA Kit for Kallikrein 1 (KLK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV845Rb01 | Recombinant Kallikrein 1 (KLK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV845Rb01 | Monoclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IP. |
| PAV845Rb01 | Polyclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV845Rb01 | CLIA Kit for Kallikrein 1 (KLK1) | CLIA assay for Antigen Detection |
| ELV845Rb01 | ELISA Kit for Kallikrein 1 (KLK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV845Mo01 | Recombinant Kallikrein 1 (KLK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV845Mo01 | Monoclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IP. |
| PAV845Mo01 | Polyclonal Antibody to Kallikrein 1 (KLK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV845Mo01 | CLIA Kit for Kallikrein 1 (KLK1) | CLIA assay for Antigen Detection |
| ELV845Mo01 | ELISA Kit for Kallikrein 1 (KLK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Nucleotide sequence of cloned cDNA for human pancreatic kallikrein."
Biochemistry 24:8037-8043(1985) [PubMed] [Europe PMC] [Abstract]
"Structure and chromosomal localization of the human renal kallikrein gene."
Biochemistry 27:3124-3129(1988) [PubMed] [Europe PMC] [Abstract]
"Cloning and expression of human salivary-gland kallikrein in Escherichia coli."
Biochem. J. 262:787-793(1989) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and characterization of a novel kallikrein transcript in colon and its distribution in human tissues."
Braz. J. Med. Biol. Res. 27:1829-1838(1994) [PubMed] [Europe PMC] [Abstract]
"Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4."
Biochem. Biophys. Res. Commun. 276:125-133(2000) [PubMed] [Europe PMC] [Abstract]
"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Human kidney kallikrein: cDNA cloning and sequence analysis."
DNA 4:445-450(1985) [PubMed] [Europe PMC] [Abstract]
"Human urinary kallikrein -- amino acid sequence and carbohydrate attachment sites."
Protein Seq. Data Anal. 1:177-182(1988) [PubMed] [Europe PMC] [Abstract]
"Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation."
Int. J. Pept. Protein Res. 33:237-249(1989) [PubMed] [Europe PMC] [Abstract]
"N-terminal amino acid sequence of human urinary kallikrein homology with other serine proteases."
Hoppe-Seyler's Z. Physiol. Chem. 360:1947-1950(1979) [PubMed] [Europe PMC] [Abstract]
"N-terminal amino acid sequence of human urinary prokallikrein."
J. Biochem. 99:989-992(1986) [PubMed] [Europe PMC] [Abstract]
"1.70 A X-ray structure of human apo kallikrein 1: structural changes upon peptide inhibitor/substrate binding."
Proteins 58:802-814(2005) [PubMed] [Europe PMC] [Abstract]
"Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity."
J. Am. Soc. Nephrol. 13:968-976(2002) [PubMed] [Europe PMC] [Abstract]
"Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans."
J. Clin. Invest. 115:780-787(2005) [PubMed] [Europe PMC] [Abstract]