Glypican 3 (GPC3)
DGSX; OCI5; SDYS; SGB; SGBS1; MXR7; Glypican Proteoglycan 3; GTR2-2; Intestinal protein OCI-5; Secreted glypican-3
Glypican 3, also known as GPC3, The protein encoded by this gene is a member of the glypican family.Glypican 3 immunostaining has utility for differentiating hepatocellular carcinoma (HCC) and dysplastic changes in cirrhotic livers; HCC stains with glypican 3, while liver with dysplastic changes and/or cirrhotic changes does not.
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV841Hu01 | Recombinant Glypican 3 (GPC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV841Hu01 | Monoclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IP. |
| PAV841Hu01 | Polyclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV841Hu01 | CLIA Kit for Glypican 3 (GPC3) | CLIA assay for Antigen Detection |
| ELV841Hu01 | ELISA Kit for Glypican 3 (GPC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV841Mu01 | Recombinant Glypican 3 (GPC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV841Mu01 | Monoclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IP. |
| PAV841Mu01 | Polyclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV841Mu01 | CLIA Kit for Glypican 3 (GPC3) | CLIA assay for Antigen Detection |
| ELV841Mu01 | ELISA Kit for Glypican 3 (GPC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV841Ra01 | Recombinant Glypican 3 (GPC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV841Ra01 | Monoclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IP. |
| PAV841Ra01 | Polyclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV841Ra01 | CLIA Kit for Glypican 3 (GPC3) | CLIA assay for Antigen Detection |
| ELV841Ra01 | ELISA Kit for Glypican 3 (GPC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV841Ca01 | Recombinant Glypican 3 (GPC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV841Ca01 | Monoclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IP. |
| PAV841Ca01 | Polyclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV841Ca01 | CLIA Kit for Glypican 3 (GPC3) | CLIA assay for Antigen Detection |
| ELV841Ca01 | ELISA Kit for Glypican 3 (GPC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV841Po01 | Recombinant Glypican 3 (GPC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV841Po01 | Monoclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IP. |
| PAV841Po01 | Polyclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV841Po01 | CLIA Kit for Glypican 3 (GPC3) | CLIA assay for Antigen Detection |
| ELV841Po01 | ELISA Kit for Glypican 3 (GPC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV841Bo01 | Recombinant Glypican 3 (GPC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV841Bo01 | Monoclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IP. |
| PAV841Bo01 | Polyclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV841Bo01 | CLIA Kit for Glypican 3 (GPC3) | CLIA assay for Antigen Detection |
| ELV841Bo01 | ELISA Kit for Glypican 3 (GPC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV841Rb01 | Recombinant Glypican 3 (GPC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV841Rb01 | Monoclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IP. |
| PAV841Rb01 | Polyclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV841Rb01 | CLIA Kit for Glypican 3 (GPC3) | CLIA assay for Antigen Detection |
| ELV841Rb01 | ELISA Kit for Glypican 3 (GPC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV841Mo01 | Recombinant Glypican 3 (GPC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV841Mo01 | Monoclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IP. |
| PAV841Mo01 | Polyclonal Antibody to Glypican 3 (GPC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV841Mo01 | CLIA Kit for Glypican 3 (GPC3) | CLIA assay for Antigen Detection |
| ELV841Mo01 | ELISA Kit for Glypican 3 (GPC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to chromosome X in human and rat by fluorescence in situ hybridization."
Mamm. Genome 8:72-72(1997) [PubMed] [Europe PMC] [Abstract]
"Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome."
Nat. Genet. 12:241-247(1996) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5."
Gene 188:151-156(1997) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
"Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene."
Genomics 45:48-58(1997) [PubMed] [Europe PMC] [Abstract]
"The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26."
Proteomics 7:2300-2310(2007) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene."
Hum. Mol. Genet. 9:1321-1328(2000) [PubMed] [Europe PMC] [Abstract]