Aldosterone Synthase (ALDOS)
CPN2; CYP11B; CYP11BL; CYP11B2; P450C18; P450aldo; Steroid 18-hydroxylase; Aldosterone-synthesizing enzyme; Cytochrome P450 Family 11 Subfamily B Polypeptide 2
Aldosterone synthase (or 18-hydroxylase) is a steroid hydroxylase cytochrome P450 oxidase enzyme involved in the generation of aldosterone. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein is primarily expressed in the zona glomerulosa of the adrenal cortex. Within the cell, it localizes to the inner membrane of the mitochondria. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV825Hu01 | Recombinant Aldosterone Synthase (ALDOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV825Hu01 | Monoclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IP. |
| PAV825Hu01 | Polyclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV825Hu01 | CLIA Kit for Aldosterone Synthase (ALDOS) | CLIA assay for Antigen Detection |
| ELV825Hu01 | ELISA Kit for Aldosterone Synthase (ALDOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV825Mu01 | Recombinant Aldosterone Synthase (ALDOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV825Mu01 | Monoclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IP. |
| PAV825Mu01 | Polyclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV825Mu01 | CLIA Kit for Aldosterone Synthase (ALDOS) | CLIA assay for Antigen Detection |
| ELV825Mu01 | ELISA Kit for Aldosterone Synthase (ALDOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV825Ra01 | Recombinant Aldosterone Synthase (ALDOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV825Ra01 | Monoclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IP. |
| PAV825Ra01 | Polyclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV825Ra01 | CLIA Kit for Aldosterone Synthase (ALDOS) | CLIA assay for Antigen Detection |
| ELV825Ra01 | ELISA Kit for Aldosterone Synthase (ALDOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV825Ca01 | Recombinant Aldosterone Synthase (ALDOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV825Ca01 | Monoclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IP. |
| PAV825Ca01 | Polyclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV825Ca01 | CLIA Kit for Aldosterone Synthase (ALDOS) | CLIA assay for Antigen Detection |
| ELV825Ca01 | ELISA Kit for Aldosterone Synthase (ALDOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV825Po01 | Recombinant Aldosterone Synthase (ALDOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV825Po01 | Monoclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IP. |
| PAV825Po01 | Polyclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV825Po01 | CLIA Kit for Aldosterone Synthase (ALDOS) | CLIA assay for Antigen Detection |
| ELV825Po01 | ELISA Kit for Aldosterone Synthase (ALDOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV825Bo01 | Recombinant Aldosterone Synthase (ALDOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV825Bo01 | Monoclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IP. |
| PAV825Bo01 | Polyclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV825Bo01 | CLIA Kit for Aldosterone Synthase (ALDOS) | CLIA assay for Antigen Detection |
| ELV825Bo01 | ELISA Kit for Aldosterone Synthase (ALDOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV825Rb01 | Recombinant Aldosterone Synthase (ALDOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV825Rb01 | Monoclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IP. |
| PAV825Rb01 | Polyclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV825Rb01 | CLIA Kit for Aldosterone Synthase (ALDOS) | CLIA assay for Antigen Detection |
| ELV825Rb01 | ELISA Kit for Aldosterone Synthase (ALDOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV825Mo01 | Recombinant Aldosterone Synthase (ALDOS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV825Mo01 | Monoclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IP. |
| PAV825Mo01 | Polyclonal Antibody to Aldosterone Synthase (ALDOS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV825Mo01 | CLIA Kit for Aldosterone Synthase (ALDOS) | CLIA assay for Antigen Detection |
| ELV825Mo01 | ELISA Kit for Aldosterone Synthase (ALDOS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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J. Biol. Chem. 264:20961-20967(1989) [PubMed] [Europe PMC] [Abstract]
"Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism."
Biochem. Biophys. Res. Commun. 173:309-316(1990) [PubMed] [Europe PMC] [Abstract]
"Structural insights into aldosterone synthase substrate specificity and targeted inhibition."
Mol. Endocrinol. 27:315-324(2013) [PubMed] [Europe PMC] [Abstract]
"Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency."
Proc. Natl. Acad. Sci. U.S.A. 89:4996-5000(1992) [PubMed] [Europe PMC] [Abstract]
"Congenitally defective aldosterone biosynthesis in humans: the involvement of point mutations of the P-450C18 gene (CYP11B2) in CMO II deficient patients."
Biochem. Biophys. Res. Commun. 182:974-979(1992) [PubMed] [Europe PMC] [Abstract]
Erratum
Biochem. Biophys. Res. Commun. 184:1529-1530(1992)
"Congenitally defective aldosterone biosynthesis in humans: inactivation of the P-450(C18) gene (CYP11B2) due to nucleotide deletion in CMO I deficient patients."
Biochem. Biophys. Res. Commun. 190:864-869(1993) [PubMed] [Europe PMC] [Abstract]
"CMO I deficiency caused by a point mutation in exon 8 of the human CYP11B2 gene encoding steroid 18-hydroxylase (P450C18)."
Biochem. Biophys. Res. Commun. 234:382-385(1997) [PubMed] [Europe PMC] [Abstract]
"Mutation THR-185 ILE is associated with corticosterone methyl oxidase deficiency type II."
Eur. J. Pediatr. 157:378-381(1998) [PubMed] [Europe PMC] [Abstract]
"Isolated aldosterone synthase deficiency caused by simultaneous E198D and V386A mutations in the CYP11B2 gene."
J. Clin. Endocrinol. Metab. 83:4156-4161(1998) [PubMed] [Europe PMC] [Abstract]
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Hypertension 33:266-270(1999) [PubMed] [Europe PMC] [Abstract]
"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
Erratum
Nat. Genet. 23:373-373(1999)
"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
"Type 1 aldosterone synthase deficiency presenting in a middle-aged man."
J. Clin. Endocrinol. Metab. 86:1008-1012(2001) [PubMed] [Europe PMC] [Abstract]
"A compound heterozygote case of type II aldosterone synthase deficiency."
J. Clin. Endocrinol. Metab. 88:2518-2526(2003) [PubMed] [Europe PMC] [Abstract]