Leukocyte Associated Immunoglobulin Like Receptor 1 (LAIR1)

CD305; hLAIR1

SPN	V808
HGNC	6477
MGI	105492
PubMed	9285412
RGD	1560048
UniProt	Q6GTX8
Wiki	LAIR1

LAIR1 is a type I membrane protein with a leader sequence, an extracellular domain, a transmembrane domain, and a cytoplasmic region. LAIR-1 is a 32 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize human leukocyte antigen (HLA) class I molecules and thus represents a novel HLA class I-independent mechanism of NK cell regulation.

 

Reference

"LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes."
Immunity 7:283-290(1997) [PubMed] [Europe PMC] [Abstract]

"Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells."
J. Immunol. 162:5800-5804(1999) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells."
J. Biol. Chem. 275:17440-17446(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor."
Eur. J. Immunol. 28:2086-2091(1998) [PubMed] [Europe PMC] [Abstract]

"Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling."
Eur. J. Immunol. 29:3160-3167(1999) [PubMed] [Europe PMC] [Abstract]

"Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias."
Eur. J. Immunol. 30:2751-2758(2000) [PubMed] [Europe PMC] [Abstract]

"Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells."
J. Immunol. 166:1763-1770(2001) [PubMed] [Europe PMC] [Abstract]

"Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions."
Hum. Immunol. 63:534-546(2002) [PubMed] [Europe PMC] [Abstract]

"Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment."
Int. Immunol. 15:1349-1358(2003) [PubMed] [Europe PMC] [Abstract]

"Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells."
J. Clin. Immunol. 23:141-145(2003) [PubMed] [Europe PMC] [Abstract]

"Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection."
Blood 103:2180-2186(2004) [PubMed] [Europe PMC] [Abstract]

"Inhibitory receptors CD85j, LAIR-1, and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes."
Clin. Diagn. Lab. Immunol. 12:705-712(2005) [PubMed] [Europe PMC] [Abstract]

"The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation."
Mol. Immunol. 42:1521-1530(2005) [PubMed] [Europe PMC] [Abstract]

"Leukocyte-associated Ig-like receptor-1 has SH2 domain-containing phosphatase-independent function and recruits C-terminal Src kinase."
Eur. J. Immunol. 36:190-198(2006) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI."
Blood 115:1364-1373(2010) [PubMed] [Europe PMC] [Abstract]