Cluster Of Differentiation 320 (CD320)
8D6; 8D6A; CD320 Antigen; TCblR; FDC-signaling molecule 8D6; Transcobalamin receptor
Transcobalamin II (TCN2), a plasma protein secreted by endothelial cells, binds the cobalamin absorbed in the distal ileum and carries 10 to 30% of total circulating cobalamin. CD320 encodes a transcobalamin receptor that binds TCN2-cobalamin at the plasma membrane and internalizes the complex by endocytosis .Functional analysis by Li et al. (2000) indicated that expression of 8D6 enhanced B-cell proliferation and immunoglobulin secretion. Treatment of the FDC cell line and a lymphoma cell line coculture with anti-8D6 resulted in at least partial inhibition of lymphoma growth. Li et al. (2000) proposed that antagonists of the 8D6 signaling pathway may counter the growth of follicular lymphomas or other tumors that metastasize to lymphoid follicles.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV805Hu01 | Recombinant Cluster Of Differentiation 320 (CD320) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV805Hu01 | Monoclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IP. |
| PAV805Hu01 | Polyclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV805Hu01 | CLIA Kit for Cluster Of Differentiation 320 (CD320) | CLIA assay for Antigen Detection |
| ELV805Hu01 | ELISA Kit for Cluster Of Differentiation 320 (CD320) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV805Mu01 | Recombinant Cluster Of Differentiation 320 (CD320) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV805Mu01 | Monoclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IP. |
| PAV805Mu01 | Polyclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV805Mu01 | CLIA Kit for Cluster Of Differentiation 320 (CD320) | CLIA assay for Antigen Detection |
| ELV805Mu01 | ELISA Kit for Cluster Of Differentiation 320 (CD320) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV805Ra01 | Recombinant Cluster Of Differentiation 320 (CD320) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV805Ra01 | Monoclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IP. |
| PAV805Ra01 | Polyclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV805Ra01 | CLIA Kit for Cluster Of Differentiation 320 (CD320) | CLIA assay for Antigen Detection |
| ELV805Ra01 | ELISA Kit for Cluster Of Differentiation 320 (CD320) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV805Ca01 | Recombinant Cluster Of Differentiation 320 (CD320) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV805Ca01 | Monoclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IP. |
| PAV805Ca01 | Polyclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV805Ca01 | CLIA Kit for Cluster Of Differentiation 320 (CD320) | CLIA assay for Antigen Detection |
| ELV805Ca01 | ELISA Kit for Cluster Of Differentiation 320 (CD320) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV805Po01 | Recombinant Cluster Of Differentiation 320 (CD320) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV805Po01 | Monoclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IP. |
| PAV805Po01 | Polyclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV805Po01 | CLIA Kit for Cluster Of Differentiation 320 (CD320) | CLIA assay for Antigen Detection |
| ELV805Po01 | ELISA Kit for Cluster Of Differentiation 320 (CD320) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV805Bo01 | Recombinant Cluster Of Differentiation 320 (CD320) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV805Bo01 | Monoclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IP. |
| PAV805Bo01 | Polyclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV805Bo01 | CLIA Kit for Cluster Of Differentiation 320 (CD320) | CLIA assay for Antigen Detection |
| ELV805Bo01 | ELISA Kit for Cluster Of Differentiation 320 (CD320) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV805Rb01 | Recombinant Cluster Of Differentiation 320 (CD320) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV805Rb01 | Monoclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IP. |
| PAV805Rb01 | Polyclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV805Rb01 | CLIA Kit for Cluster Of Differentiation 320 (CD320) | CLIA assay for Antigen Detection |
| ELV805Rb01 | ELISA Kit for Cluster Of Differentiation 320 (CD320) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV805Mo01 | Recombinant Cluster Of Differentiation 320 (CD320) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV805Mo01 | Monoclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IP. |
| PAV805Mo01 | Polyclonal Antibody to Cluster Of Differentiation 320 (CD320) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV805Mo01 | CLIA Kit for Cluster Of Differentiation 320 (CD320) | CLIA assay for Antigen Detection |
| ELV805Mo01 | ELISA Kit for Cluster Of Differentiation 320 (CD320) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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J. Immunol. 167:49-56(2001) [PubMed] [Europe PMC] [Abstract]
"The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin."
Blood 113:186-192(2009) [PubMed] [Europe PMC] [Abstract]
"Positive newborn screen for methylmalonic aciduria identifies the first mutation in TCblR/CD320, the gene for cellular uptake of transcobalamin-bound vitamin B(12)."
Hum. Mutat. 31:924-929(2010) [PubMed] [Europe PMC] [Abstract]