Alpha-Lactalbumin (aLA)
LALBA; LYZL7; Lactose Synthase B Protein; Lysozyme Like Protein 7
Alpha-lactalbumin is an important whey protein in cow's milk (~1 g/l), and is also present in the milk of many other mammalian species. In primates, alpha-lactalbumin expression is upregulated in response to the hormone prolactin and increases the production of lactose. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta-1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transferring galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV794Hu01 | Recombinant Alpha-Lactalbumin (aLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV794Hu01 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. |
| PAV794Hu01 | Polyclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV794Hu01 | CLIA Kit for Alpha-Lactalbumin (aLA) | CLIA assay for Antigen Detection |
| ELV794Hu01 | ELISA Kit for Alpha-Lactalbumin (aLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV794Mu01 | Recombinant Alpha-Lactalbumin (aLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV794Mu01 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. |
| PAV794Mu01 | Polyclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV794Mu01 | CLIA Kit for Alpha-Lactalbumin (aLA) | CLIA assay for Antigen Detection |
| ELV794Mu01 | ELISA Kit for Alpha-Lactalbumin (aLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV794Ra01 | Recombinant Alpha-Lactalbumin (aLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV794Ra01 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. |
| PAV794Ra01 | Polyclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV794Ra01 | CLIA Kit for Alpha-Lactalbumin (aLA) | CLIA assay for Antigen Detection |
| ELV794Ra01 | ELISA Kit for Alpha-Lactalbumin (aLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV794Ca01 | Recombinant Alpha-Lactalbumin (aLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV794Ca01 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. |
| PAV794Ca01 | Polyclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV794Ca01 | CLIA Kit for Alpha-Lactalbumin (aLA) | CLIA assay for Antigen Detection |
| ELV794Ca01 | ELISA Kit for Alpha-Lactalbumin (aLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV794Po01 | Recombinant Alpha-Lactalbumin (aLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV794Po01 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. |
| PAV794Po01 | Polyclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV794Po01 | CLIA Kit for Alpha-Lactalbumin (aLA) | CLIA assay for Antigen Detection |
| ELV794Po01 | ELISA Kit for Alpha-Lactalbumin (aLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV794Bo01 | Recombinant Alpha-Lactalbumin (aLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV794Bo01 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. |
| PAV794Bo01 | Polyclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV794Bo01 | CLIA Kit for Alpha-Lactalbumin (aLA) | CLIA assay for Antigen Detection |
| ELV794Bo01 | ELISA Kit for Alpha-Lactalbumin (aLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV794Rb01 | Recombinant Alpha-Lactalbumin (aLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV794Rb01 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. |
| PAV794Rb01 | Polyclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV794Rb01 | CLIA Kit for Alpha-Lactalbumin (aLA) | CLIA assay for Antigen Detection |
| ELV794Rb01 | ELISA Kit for Alpha-Lactalbumin (aLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV794Mo01 | Recombinant Alpha-Lactalbumin (aLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV794Mo01 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. |
| PAV794Mo01 | Polyclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV794Mo01 | CLIA Kit for Alpha-Lactalbumin (aLA) | CLIA assay for Antigen Detection |
| ELV794Mo01 | ELISA Kit for Alpha-Lactalbumin (aLA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Comparison of the nucleotide sequence of cloned human and guinea-pig pre-alpha-lactalbumin cDNA with that of chick pre-lysozyme cDNA suggests evolution from a common ancestral gene."
Nucleic Acids Res. 10:3503-3515(1982) [PubMed] [Europe PMC] [Abstract]
"Organization and sequence of the human alpha-lactalbumin gene."
Biochem. J. 242:735-742(1987) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The complete amino-acid sequence of human alpha-lactalbumin."
Eur. J. Biochem. 27:65-86(1972) [PubMed] [Europe PMC] [Abstract]
"Identification of a new molecular form of human alpha-lactalbumin."
J. Dairy Res. 59:425-429(1992) [PubMed] [Europe PMC] [Abstract]
"An unusual glycosylation site in alpha-lactalbumin from human milk."
Protein Sci. 4 Suppl. 1:119-119(1995)
"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human alpha-lactalbumin at 1.7-A resolution."
J. Mol. Biol. 221:571-581(1991) [PubMed] [Europe PMC] [Abstract]
"Alpha-lactalbumin possesses a distinct zinc binding site."
J. Biol. Chem. 268:19292-19298(1993) [PubMed] [Europe PMC] [Abstract]
"Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin."
Biochemistry 37:4767-4772(1998) [PubMed] [Europe PMC] [Abstract]
"Crystallographic evaluation of internal motion of human alpha-lactalbumin refined by full-matrix least-squares method."
J. Mol. Biol. 287:347-358(1999) [PubMed] [Europe PMC] [Abstract]
"Detection of a single nucleotide polymorphism in the human alpha-lactalbumin gene: implications for human milk proteins."
J. Nutr. Biochem. 16:272-278(2005) [PubMed] [Europe PMC] [Abstract]