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Protein Kinase C Beta 1 (PKCb1)

PKC-B1; PRKCB; PRKCB1

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.

  • Protein Kinase C Beta 1 is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV767Hu01 Recombinant Protein Kinase C Beta 1 (PKCb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV767Hu01 Monoclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
PAV767Hu01 Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IF.
Assay Kits CLV767Hu01 CLIA Kit for Protein Kinase C Beta 1 (PKCb1) CLIA assay for Antigen Detection
ELV767Hu01 ELISA Kit for Protein Kinase C Beta 1 (PKCb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV767Mu01 Recombinant Protein Kinase C Beta 1 (PKCb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV767Mu01 Monoclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
PAV767Mu01 Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IF.
Assay Kits CLV767Mu01 CLIA Kit for Protein Kinase C Beta 1 (PKCb1) CLIA assay for Antigen Detection
ELV767Mu01 ELISA Kit for Protein Kinase C Beta 1 (PKCb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV767Ra01 Recombinant Protein Kinase C Beta 1 (PKCb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV767Ra01 Monoclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
PAV767Ra01 Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IF.
Assay Kits CLV767Ra01 CLIA Kit for Protein Kinase C Beta 1 (PKCb1) CLIA assay for Antigen Detection
ELV767Ra01 ELISA Kit for Protein Kinase C Beta 1 (PKCb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV767Ca01 Recombinant Protein Kinase C Beta 1 (PKCb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV767Ca01 Monoclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
PAV767Ca01 Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IF.
Assay Kits CLV767Ca01 CLIA Kit for Protein Kinase C Beta 1 (PKCb1) CLIA assay for Antigen Detection
ELV767Ca01 ELISA Kit for Protein Kinase C Beta 1 (PKCb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV767Po01 Recombinant Protein Kinase C Beta 1 (PKCb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV767Po01 Monoclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
PAV767Po01 Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IF.
Assay Kits CLV767Po01 CLIA Kit for Protein Kinase C Beta 1 (PKCb1) CLIA assay for Antigen Detection
ELV767Po01 ELISA Kit for Protein Kinase C Beta 1 (PKCb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV767Bo01 Recombinant Protein Kinase C Beta 1 (PKCb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV767Bo01 Monoclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
PAV767Bo01 Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IF.
Assay Kits CLV767Bo01 CLIA Kit for Protein Kinase C Beta 1 (PKCb1) CLIA assay for Antigen Detection
ELV767Bo01 ELISA Kit for Protein Kinase C Beta 1 (PKCb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV767Rb01 Recombinant Protein Kinase C Beta 1 (PKCb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV767Rb01 Monoclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
PAV767Rb01 Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IF.
Assay Kits CLV767Rb01 CLIA Kit for Protein Kinase C Beta 1 (PKCb1) CLIA assay for Antigen Detection
ELV767Rb01 ELISA Kit for Protein Kinase C Beta 1 (PKCb1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV767Mo01 Recombinant Protein Kinase C Beta 1 (PKCb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV767Mo01 Monoclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
PAV767Mo01 Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IF.
Assay Kits CLV767Mo01 CLIA Kit for Protein Kinase C Beta 1 (PKCb1) CLIA assay for Antigen Detection
ELV767Mo01 ELISA Kit for Protein Kinase C Beta 1 (PKCb1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Science 233:859-866(1986) [PubMed] [Europe PMC] [Abstract]

"Primary structures of human protein kinase C beta I and beta II differ only in their C-terminal sequences."
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Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Autoregulation of cloned human protein kinase C beta and gamma gene promoters in U937 cells."
DNA Cell Biol. 14:213-222(1995) [PubMed] [Europe PMC] [Abstract]

"Positive and negative regulation of the transcription of the human protein kinase C beta gene."
J. Biol. Chem. 267:6158-6163(1992) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters."
J. Biol. Chem. 267:20804-20810(1992) [PubMed] [Europe PMC] [Abstract]

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing increases the diversity of the human protein kinase C family."
DNA 6:389-394(1987) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta-I/beta-II."
Nucleic Acids Res. 15:7179-7180(1987) [PubMed] [Europe PMC] [Abstract]

"PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization."
EMBO J. 20:5692-5702(2001) [PubMed] [Europe PMC] [Abstract]

"The protein kinase Cbeta-selective inhibitor, enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts."
Cancer Res. 65:7462-7469(2005) [PubMed] [Europe PMC] [Abstract]

"The phosphatase PHLPP controls the cellular levels of protein kinase C."
J. Biol. Chem. 283:6300-6311(2008) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of activation transcription factor-2 at serine 121 by protein kinase c controls c-Jun-mediated activation of transcription."
J. Biol. Chem. 284:8567-8581(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4."
Nature 464:792-796(2010) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C beta (PKC beta): normal functions and diseases."
J. Biochem. 132:677-682(2002) [PubMed] [Europe PMC] [Abstract]

"Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications."
Rev. Endocr. Metab. Disord. 11:61-74(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor."
Biochemistry 45:13970-13981(2006) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]