Fucosyltransferase 4 (FUT4)

CD15; 3FAL; FCT3A, ELFT, SSEA-1, LeX; Lewis x; Stage Specific Embryonic Antigen 1; 3-Fucosyl-N-Acetyl Lactosamine; Alpha(1,3)Fucosyltransferase,Myeloid-Specific

SPN	V753
HGNC	4015
MGI	95594
PubMed	22287018
RGD	619954
UniProt	P22083
Wiki	FUT4

Twenty antibodies, all of which bound specifically to the surface of human myeloid cells, exhibited similar reactivity patterns with the hybrid clones. Chromosomal analysis showed that the gene or genes involved in expression of the 1 or more antigens recognized by these antibodies must be located on human chromosome 11q12-qter. This myeloid-associated surface antigen was designated CD15 in the CD system.Analysis of fetal tissues revealed abundant expression in liver, muscle, kidney, skin, and small intestine, and moderate expression in brain, lung, and heart. The transcript size varied in different tissues. In adult tissues, highest expression was found in lung and small intestine, low expression in kidney, liver, and brain, and no expression in 12 other tissues tested.

Reference

"ELFT: a gene that directs the expression of an ELAM-1 ligand."
Cell 63:1349-1356(1990) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants."
J. Biol. Chem. 266:21777-21783(1991) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion."
J. Biol. Chem. 266:17467-17477(1991) [PubMed] [Europe PMC] [Abstract]