Bone Sialoprotein (BSP)
IBSP; Bsp; BspII; SpII; Integrin-Binding Bone Sialoprotein; Cell-binding sialoprotein; Bone sialoprotein 2
Bone sialoprotein (BSP) is a component of mineralized tissues such as bone, dentin, cementum and calcified cartilage. BSP is a significant component of the bone extracellular matrix and has been suggested to constitute approximately 8% of all non-collagenous proteins found in bone and cementum. BSP was originally isolated from bovine cortical bone as a 23-kDa glycopeptide with high sialic acid content, as described in separate reports by Williams and Peacocke and Andrews and Herring Native BSP has an apparent molecular weight of 60-80 kDa based on SDS-PAGE, which is a considerable deviation from the predicted weight of approximately 33 kDa. The mammalian BSP cDNAs encode for proteins averaging 327 amino acids,, which includes the 16-residue preprotein secretory signal peptide.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV721Hu01 | Recombinant Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV721Hu01 | Monoclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IP. |
| PAV721Hu01 | Polyclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV721Hu01 | CLIA Kit for Bone Sialoprotein (BSP) | CLIA assay for Antigen Detection |
| ELV721Hu01 | ELISA Kit for Bone Sialoprotein (BSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV721Mu01 | Recombinant Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV721Mu01 | Monoclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IP. |
| PAV721Mu01 | Polyclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV721Mu01 | CLIA Kit for Bone Sialoprotein (BSP) | CLIA assay for Antigen Detection |
| ELV721Mu01 | ELISA Kit for Bone Sialoprotein (BSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV721Ra01 | Recombinant Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV721Ra01 | Monoclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IP. |
| PAV721Ra01 | Polyclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV721Ra01 | CLIA Kit for Bone Sialoprotein (BSP) | CLIA assay for Antigen Detection |
| ELV721Ra01 | ELISA Kit for Bone Sialoprotein (BSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV721Ca01 | Recombinant Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV721Ca01 | Monoclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IP. |
| PAV721Ca01 | Polyclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV721Ca01 | CLIA Kit for Bone Sialoprotein (BSP) | CLIA assay for Antigen Detection |
| ELV721Ca01 | ELISA Kit for Bone Sialoprotein (BSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV721Po01 | Recombinant Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV721Po01 | Monoclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IP. |
| PAV721Po01 | Polyclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV721Po01 | CLIA Kit for Bone Sialoprotein (BSP) | CLIA assay for Antigen Detection |
| ELV721Po01 | ELISA Kit for Bone Sialoprotein (BSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV721Bo01 | Recombinant Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV721Bo01 | Monoclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IP. |
| PAV721Bo01 | Polyclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV721Bo01 | CLIA Kit for Bone Sialoprotein (BSP) | CLIA assay for Antigen Detection |
| ELV721Bo01 | ELISA Kit for Bone Sialoprotein (BSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV721Rb01 | Recombinant Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV721Rb01 | Monoclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IP. |
| PAV721Rb01 | Polyclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV721Rb01 | CLIA Kit for Bone Sialoprotein (BSP) | CLIA assay for Antigen Detection |
| ELV721Rb01 | ELISA Kit for Bone Sialoprotein (BSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV721Mo01 | Recombinant Bone Sialoprotein (BSP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV721Mo01 | Monoclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IP. |
| PAV721Mo01 | Polyclonal Antibody to Bone Sialoprotein (BSP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV721Mo01 | CLIA Kit for Bone Sialoprotein (BSP) | CLIA assay for Antigen Detection |
| ELV721Mo01 | ELISA Kit for Bone Sialoprotein (BSP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human bone sialoprotein. Deduced protein sequence and chromosomal localization."
J. Biol. Chem. 265:2347-2351(1990) [PubMed] [Europe PMC] [Abstract]
"The human bone sialoprotein gene (IBSP): genomic localization and characterization."
Genomics 17:408-415(1993) [PubMed] [Europe PMC] [Abstract]
"Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence."
Matrix Biol. 14:31-40(1994) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone."
J. Biol. Chem. 262:9702-9708(1987) [PubMed] [Europe PMC] [Abstract]
"Structural characterization of human recombinant and bone-derived bone sialoprotein. Functional implications for cell attachment and hydroxyapatite binding."
J. Biol. Chem. 276:36839-36848(2001) [PubMed] [Europe PMC] [Abstract]
"Posttranslational modifications to human bone sialoprotein determined by mass spectrometry."
Biochemistry 40:12983-12991(2001) [PubMed] [Europe PMC] [Abstract]