Nucleoporin 50kDa (NUP50)
NPAP60; NPAP60L; Nuclear pore-associated protein 60 kDa-like
Nucleoporin 50 kDa is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. NUP50 is a tristable switch that alternates between binding modes.
The C terminus binds importin-beta through RAN-GTP. The N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta. NUP50:importin-alpha:importin-beta binds cargo and can stimulate nuclear import. Endogenous NUP50 can shuttle and is accessible from the cytoplasmic side of the nuclear envelope. These findings identified NUP50 as a cofactor for importin-alpha:importin-beta nuclear import and as a subunit of the importin complex.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV712Hu01 | Recombinant Nucleoporin 50kDa (NUP50) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV712Hu01 | Monoclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IP. |
| PAV712Hu01 | Polyclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV712Hu01 | CLIA Kit for Nucleoporin 50kDa (NUP50) | CLIA assay for Antigen Detection |
| ELV712Hu01 | ELISA Kit for Nucleoporin 50kDa (NUP50) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV712Mu01 | Recombinant Nucleoporin 50kDa (NUP50) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV712Mu01 | Monoclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IP. |
| PAV712Mu01 | Polyclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV712Mu01 | CLIA Kit for Nucleoporin 50kDa (NUP50) | CLIA assay for Antigen Detection |
| ELV712Mu01 | ELISA Kit for Nucleoporin 50kDa (NUP50) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV712Ra01 | Recombinant Nucleoporin 50kDa (NUP50) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV712Ra01 | Monoclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IP. |
| PAV712Ra01 | Polyclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV712Ra01 | CLIA Kit for Nucleoporin 50kDa (NUP50) | CLIA assay for Antigen Detection |
| ELV712Ra01 | ELISA Kit for Nucleoporin 50kDa (NUP50) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV712Ca01 | Recombinant Nucleoporin 50kDa (NUP50) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV712Ca01 | Monoclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IP. |
| PAV712Ca01 | Polyclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV712Ca01 | CLIA Kit for Nucleoporin 50kDa (NUP50) | CLIA assay for Antigen Detection |
| ELV712Ca01 | ELISA Kit for Nucleoporin 50kDa (NUP50) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV712Po01 | Recombinant Nucleoporin 50kDa (NUP50) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV712Po01 | Monoclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IP. |
| PAV712Po01 | Polyclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV712Po01 | CLIA Kit for Nucleoporin 50kDa (NUP50) | CLIA assay for Antigen Detection |
| ELV712Po01 | ELISA Kit for Nucleoporin 50kDa (NUP50) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV712Bo01 | Recombinant Nucleoporin 50kDa (NUP50) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV712Bo01 | Monoclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IP. |
| PAV712Bo01 | Polyclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV712Bo01 | CLIA Kit for Nucleoporin 50kDa (NUP50) | CLIA assay for Antigen Detection |
| ELV712Bo01 | ELISA Kit for Nucleoporin 50kDa (NUP50) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV712Rb01 | Recombinant Nucleoporin 50kDa (NUP50) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV712Rb01 | Monoclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IP. |
| PAV712Rb01 | Polyclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV712Rb01 | CLIA Kit for Nucleoporin 50kDa (NUP50) | CLIA assay for Antigen Detection |
| ELV712Rb01 | ELISA Kit for Nucleoporin 50kDa (NUP50) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV712Mo01 | Recombinant Nucleoporin 50kDa (NUP50) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV712Mo01 | Monoclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IP. |
| PAV712Mo01 | Polyclonal Antibody to Nucleoporin 50kDa (NUP50) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV712Mo01 | CLIA Kit for Nucleoporin 50kDa (NUP50) | CLIA assay for Antigen Detection |
| ELV712Mo01 | ELISA Kit for Nucleoporin 50kDa (NUP50) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Submitted (AUG-2007) to the PDB data bank