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Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1)

CD39; ATPDase; NTPDase-1; Ecto-ATP diphosphohydrolase 1; Ecto-apyrase; Lymphoid cell activation antigen

Endothelial cells have the ability to regulate platelet activation, in part by the surface expression of ATP diphosphohydrolase (ATPDase; EC 3.6.1.5). ATPDase hydrolyzes extracellular ATP and ADP to AMP, which is further converted to adenosine by another enzyme, 5-prime nucleotidase. ADP is a powerful agonist for platelet recruitment and adhesion; adenosine is an antagonist of these processes. 

CD39 was found to have both immunologic identity to, and functional characteristics of, vascular ATPDase. By Northern blot analysis, Chadwick and Frischauf (1998) found that CD39 is expressed as a major 3.2- and a minor 3.6-kb mRNA in several tissues. Additional bands were observed in a few tissues.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV695Hu01 Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV695Hu01 Monoclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IP.
PAV695Hu01 Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IF.
Assay Kits CLV695Hu01 CLIA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) CLIA assay for Antigen Detection
ELV695Hu01 ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV695Mu01 Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV695Mu01 Monoclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IP.
PAV695Mu01 Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IF.
Assay Kits CLV695Mu01 CLIA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) CLIA assay for Antigen Detection
ELV695Mu01 ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV695Ra01 Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV695Ra01 Monoclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IP.
PAV695Ra01 Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IF.
Assay Kits CLV695Ra01 CLIA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) CLIA assay for Antigen Detection
ELV695Ra01 ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV695Ca01 Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV695Ca01 Monoclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IP.
PAV695Ca01 Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IF.
Assay Kits CLV695Ca01 CLIA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) CLIA assay for Antigen Detection
ELV695Ca01 ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV695Po01 Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV695Po01 Monoclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IP.
PAV695Po01 Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IF.
Assay Kits CLV695Po01 CLIA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) CLIA assay for Antigen Detection
ELV695Po01 ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV695Bo01 Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV695Bo01 Monoclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IP.
PAV695Bo01 Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IF.
Assay Kits CLV695Bo01 CLIA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) CLIA assay for Antigen Detection
ELV695Bo01 ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV695Rb01 Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV695Rb01 Monoclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IP.
PAV695Rb01 Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IF.
Assay Kits CLV695Rb01 CLIA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) CLIA assay for Antigen Detection
ELV695Rb01 ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV695Mo01 Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV695Mo01 Monoclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IP.
PAV695Mo01 Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IF.
Assay Kits CLV695Mo01 CLIA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) CLIA assay for Antigen Detection
ELV695Mo01 ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization."
J. Immunol. 153:3574-3583(1994) [PubMed] [Europe PMC] [Abstract]

"Loss of ATP diphosphohydrolase activity with endothelial cell activation."
J. Exp. Med. 185:153-163(1997) [PubMed] [Europe PMC] [Abstract]

"The cDNA cloning of human placental ecto-ATP diphosphohydrolases I and II."
FEBS Lett. 453:335-340(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Purification and properties of human placental ATP diphosphohydrolase."
Eur. J. Biochem. 234:66-74(1995) [PubMed] [Europe PMC] [Abstract]

"Placental ecto-ATP diphosphohydrolase: its structural feature distinct from CD39, localization and inhibition on shear-induced platelet aggregation."
Int. J. Hematol. 68:297-310(1998) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of CD39/vascular ATP diphosphohydrolase."
J. Biol. Chem. 271:33116-33122(1996) [PubMed] [Europe PMC] [Abstract]

"CD39 is an ecto-(Ca2+,Mg2+)-apyrase."
J. Biol. Chem. 271:9898-9901(1996) [PubMed] [Europe PMC] [Abstract]

"Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae."
J. Biol. Chem. 275:2057-2062(2000) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders."
Science 343:506-511(2014) [PubMed] [Europe PMC] [Abstract]