Small Nuclear Ribonucleoprotein Polypeptide D1 (SNRPD1)

SMD1; SNRP-D1; Sm-D autoantigen; snRNP core protein D1

SPN	V685
HGNC	11158
MGI	98344
RGD	1306345
UniProt	P62314

Small nuclear ribonucleoprotein Sm D1 is a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA.A clone was obtained that encoded a predicted 357-amino acid protein with 9 Gly-Arg repeats at its carboxy terminus similar to regions in the Epstein-Barr virus nuclear proteins EBNA-1 and EBNA-2, as well as the yeast transcription factor SNF2 .Lehmeier et al. (1994) showed that the D1 amino acid sequence is 29% identical to D3 and less than 15% identical to D2. The authors also showed that sera from 3 patients with lupus erythematosus detected the D1 and D3 components twice and the D2 component 3 times.

Reference

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"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln."
Curr. Biol. 11:1990-1994(2001) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]

"The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."
RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract]

"Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins."
J. Cell Biol. 178:733-740(2007) [PubMed] [Europe PMC] [Abstract]

"An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."
Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]

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BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs."
Cell 96:375-387(1999) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution."
Nature 458:475-480(2009) [PubMed] [Europe PMC] [Abstract]

"Functional organization of the Sm core in the crystal structure of human U1 snRNP."
EMBO J. 29:4172-4184(2010) [PubMed] [Europe PMC] [Abstract]

"Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis."
Nature 473:536-539(2011) [PubMed] [Europe PMC] [Abstract]

"Structural basis of assembly chaperone-mediated snRNP formation."
Mol. Cell 49:692-703(2013) [PubMed] [Europe PMC] [Abstract]