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Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1)

CD20; MS4-A1; B1; Bp35; LEU16; MS4-A2; S7; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1

Membrane-spanning 4-domains, subfamily A, member 1, also known as MS4A1, is a human gene.This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues.

This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV672Hu01 Recombinant Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV672Hu01 Monoclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IP.
PAV672Hu01 Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IF.
Assay Kits CLV672Hu01 CLIA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) CLIA assay for Antigen Detection
ELV672Hu01 ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV672Mu01 Recombinant Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV672Mu01 Monoclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IP.
PAV672Mu01 Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IF.
Assay Kits CLV672Mu01 CLIA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) CLIA assay for Antigen Detection
ELV672Mu01 ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV672Ra01 Recombinant Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV672Ra01 Monoclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IP.
PAV672Ra01 Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IF.
Assay Kits CLV672Ra01 CLIA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) CLIA assay for Antigen Detection
ELV672Ra01 ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV672Ca01 Recombinant Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV672Ca01 Monoclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IP.
PAV672Ca01 Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IF.
Assay Kits CLV672Ca01 CLIA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) CLIA assay for Antigen Detection
ELV672Ca01 ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV672Po01 Recombinant Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV672Po01 Monoclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IP.
PAV672Po01 Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IF.
Assay Kits CLV672Po01 CLIA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) CLIA assay for Antigen Detection
ELV672Po01 ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV672Bo01 Recombinant Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV672Bo01 Monoclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IP.
PAV672Bo01 Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IF.
Assay Kits CLV672Bo01 CLIA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) CLIA assay for Antigen Detection
ELV672Bo01 ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV672Rb01 Recombinant Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV672Rb01 Monoclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IP.
PAV672Rb01 Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IF.
Assay Kits CLV672Rb01 CLIA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) CLIA assay for Antigen Detection
ELV672Rb01 ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV672Mo01 Recombinant Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV672Mo01 Monoclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IP.
PAV672Mo01 Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) WB; IHC; ICC; IF.
Assay Kits CLV672Mo01 CLIA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) CLIA assay for Antigen Detection
ELV672Mo01 ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (MS4A1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III integral membrane protein."
J. Exp. Med. 167:1975-1980(1988) [PubMed] [Europe PMC] [Abstract]

"Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes."
Proc. Natl. Acad. Sci. U.S.A. 85:208-212(1988) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains."
EMBO J. 7:711-717(1988) [PubMed] [Europe PMC] [Abstract]

"Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1)."
J. Immunol. 142:2560-2568(1989) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20."
J. Immunol. 177:362-371(2006) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]

"CD20 deficiency in humans results in impaired T cell-independent antibody responses."
J. Clin. Invest. 120:214-222(2010) [PubMed] [Europe PMC] [Abstract]

"Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23."
PLoS ONE 7:E37187-E37187(2012) [PubMed] [Europe PMC] [Abstract]

"Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies."
Blood 118:358-367(2011) [PubMed] [Europe PMC] [Abstract]