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Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2)

CD85d; LILR-B2; ILT4; LIR-2; LIR2; MIR10; CD85 antigen-like family member D; Immunoglobulin-like transcript 4; Monocyte/macrophage immunoglobulin-like receptor 10

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV669Hu01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV669Hu01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IP.
PAV669Hu01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IF.
Assay Kits CLV669Hu01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) CLIA assay for Antigen Detection
ELV669Hu01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV669Mu01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV669Mu01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IP.
PAV669Mu01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IF.
Assay Kits CLV669Mu01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) CLIA assay for Antigen Detection
ELV669Mu01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV669Ra01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV669Ra01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IP.
PAV669Ra01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IF.
Assay Kits CLV669Ra01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) CLIA assay for Antigen Detection
ELV669Ra01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV669Ca01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV669Ca01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IP.
PAV669Ca01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IF.
Assay Kits CLV669Ca01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) CLIA assay for Antigen Detection
ELV669Ca01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV669Po01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV669Po01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IP.
PAV669Po01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IF.
Assay Kits CLV669Po01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) CLIA assay for Antigen Detection
ELV669Po01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV669Bo01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV669Bo01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IP.
PAV669Bo01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IF.
Assay Kits CLV669Bo01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) CLIA assay for Antigen Detection
ELV669Bo01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV669Rb01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV669Rb01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IP.
PAV669Rb01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IF.
Assay Kits CLV669Rb01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) CLIA assay for Antigen Detection
ELV669Rb01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV669Mo01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV669Mo01 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IP.
PAV669Mo01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) WB; IHC; ICC; IF.
Assay Kits CLV669Mo01 CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) CLIA assay for Antigen Detection
ELV669Mo01 ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 2 (LILRB2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells."
J. Exp. Med. 186:1809-1818(1997) [PubMed] [Europe PMC] [Abstract]

"A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes."
Eur. J. Immunol. 28:3423-3434(1998) [PubMed] [Europe PMC] [Abstract]

"Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4."
Nat. Immunol. 3:237-243(2002) [PubMed] [Europe PMC] [Abstract]

"Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G."
Proc. Natl. Acad. Sci. U.S.A. 100:8856-8861(2003) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the human cytomegalovirus class I MHC homolog UL18."
BMC Struct. Biol. 2:6-6(2002) [PubMed] [Europe PMC] [Abstract]