Phospholipid Scramblase 2 (PLSCR2)
PL scramblase 2; Ca(2+)-dependent phospholipid scramblase 2
Using the sequence of PLSCR1 as query, Wiedmer et al. (2000) identified an EST containing PLSCR2, and they cloned the full-length cDNA by PCR of erythroleukemia cell and multiple-tissue cDNA libraries.
The deduced 224-amino acid protein shares 59% identity with PLSCR1, with most of the identity in the C-terminal region, which includes a Ca(2+)-binding site.
PLSCR2 lacks the proline-rich N-terminal region that, in other members of the PLSCR family, contains PxxP motifs that bind proteins containing SH3 or WW domains. Northern blot analysis revealed a 1.6-kb transcript expressed only in testis. Trace amounts of PLSCR2 could be amplified from the erythroleukemia cell line after several rounds of PCR.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV659Hu01 | Recombinant Phospholipid Scramblase 2 (PLSCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV659Hu01 | Monoclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IP. |
| PAV659Hu01 | Polyclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV659Hu01 | CLIA Kit for Phospholipid Scramblase 2 (PLSCR2) | CLIA assay for Antigen Detection |
| ELV659Hu01 | ELISA Kit for Phospholipid Scramblase 2 (PLSCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV659Mu01 | Recombinant Phospholipid Scramblase 2 (PLSCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV659Mu01 | Monoclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IP. |
| PAV659Mu01 | Polyclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV659Mu01 | CLIA Kit for Phospholipid Scramblase 2 (PLSCR2) | CLIA assay for Antigen Detection |
| ELV659Mu01 | ELISA Kit for Phospholipid Scramblase 2 (PLSCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV659Ra01 | Recombinant Phospholipid Scramblase 2 (PLSCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV659Ra01 | Monoclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IP. |
| PAV659Ra01 | Polyclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV659Ra01 | CLIA Kit for Phospholipid Scramblase 2 (PLSCR2) | CLIA assay for Antigen Detection |
| ELV659Ra01 | ELISA Kit for Phospholipid Scramblase 2 (PLSCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV659Ca01 | Recombinant Phospholipid Scramblase 2 (PLSCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV659Ca01 | Monoclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IP. |
| PAV659Ca01 | Polyclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV659Ca01 | CLIA Kit for Phospholipid Scramblase 2 (PLSCR2) | CLIA assay for Antigen Detection |
| ELV659Ca01 | ELISA Kit for Phospholipid Scramblase 2 (PLSCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV659Po01 | Recombinant Phospholipid Scramblase 2 (PLSCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV659Po01 | Monoclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IP. |
| PAV659Po01 | Polyclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV659Po01 | CLIA Kit for Phospholipid Scramblase 2 (PLSCR2) | CLIA assay for Antigen Detection |
| ELV659Po01 | ELISA Kit for Phospholipid Scramblase 2 (PLSCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV659Bo01 | Recombinant Phospholipid Scramblase 2 (PLSCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV659Bo01 | Monoclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IP. |
| PAV659Bo01 | Polyclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV659Bo01 | CLIA Kit for Phospholipid Scramblase 2 (PLSCR2) | CLIA assay for Antigen Detection |
| ELV659Bo01 | ELISA Kit for Phospholipid Scramblase 2 (PLSCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV659Rb01 | Recombinant Phospholipid Scramblase 2 (PLSCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV659Rb01 | Monoclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IP. |
| PAV659Rb01 | Polyclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV659Rb01 | CLIA Kit for Phospholipid Scramblase 2 (PLSCR2) | CLIA assay for Antigen Detection |
| ELV659Rb01 | ELISA Kit for Phospholipid Scramblase 2 (PLSCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV659Mo01 | Recombinant Phospholipid Scramblase 2 (PLSCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV659Mo01 | Monoclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IP. |
| PAV659Mo01 | Polyclonal Antibody to Phospholipid Scramblase 2 (PLSCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV659Mo01 | CLIA Kit for Phospholipid Scramblase 2 (PLSCR2) | CLIA assay for Antigen Detection |
| ELV659Mo01 | ELISA Kit for Phospholipid Scramblase 2 (PLSCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification of three new members of the phospholipid scramblase gene family."
Biochim. Biophys. Acta 1467:244-253(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"N-terminal proline-rich domain is required for scrambling activity of human phospholipid scramblases."
J. Biol. Chem. 289:13206-13218(2014) [PubMed] [Europe PMC] [Abstract]