Cluster Of Differentiation 4 (CD4)
CD4mut; p55; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3
CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984.In humans, the CD4 protein is encoded by the CD4 gene. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR by recruiting an enzyme, known as the tyrosine kinase lck, which is essential for activating many molecules involved in the signaling cascade of an activated T cell.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV655Hu01 | Recombinant Cluster Of Differentiation 4 (CD4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV655Hu01 | Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IP. |
| PAV655Hu01 | Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV655Hu01 | CLIA Kit for Cluster Of Differentiation 4 (CD4) | CLIA assay for Antigen Detection |
| ELV655Hu01 | ELISA Kit for Cluster Of Differentiation 4 (CD4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV655Mu01 | Recombinant Cluster Of Differentiation 4 (CD4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV655Mu01 | Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IP. |
| PAV655Mu01 | Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV655Mu01 | CLIA Kit for Cluster Of Differentiation 4 (CD4) | CLIA assay for Antigen Detection |
| ELV655Mu01 | ELISA Kit for Cluster Of Differentiation 4 (CD4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV655Ra01 | Recombinant Cluster Of Differentiation 4 (CD4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV655Ra01 | Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IP. |
| PAV655Ra01 | Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV655Ra01 | CLIA Kit for Cluster Of Differentiation 4 (CD4) | CLIA assay for Antigen Detection |
| ELV655Ra01 | ELISA Kit for Cluster Of Differentiation 4 (CD4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV655Ca01 | Recombinant Cluster Of Differentiation 4 (CD4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV655Ca01 | Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IP. |
| PAV655Ca01 | Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV655Ca01 | CLIA Kit for Cluster Of Differentiation 4 (CD4) | CLIA assay for Antigen Detection |
| ELV655Ca01 | ELISA Kit for Cluster Of Differentiation 4 (CD4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV655Po01 | Recombinant Cluster Of Differentiation 4 (CD4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV655Po01 | Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IP. |
| PAV655Po01 | Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV655Po01 | CLIA Kit for Cluster Of Differentiation 4 (CD4) | CLIA assay for Antigen Detection |
| ELV655Po01 | ELISA Kit for Cluster Of Differentiation 4 (CD4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV655Bo01 | Recombinant Cluster Of Differentiation 4 (CD4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV655Bo01 | Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IP. |
| PAV655Bo01 | Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV655Bo01 | CLIA Kit for Cluster Of Differentiation 4 (CD4) | CLIA assay for Antigen Detection |
| ELV655Bo01 | ELISA Kit for Cluster Of Differentiation 4 (CD4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV655Rb01 | Recombinant Cluster Of Differentiation 4 (CD4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV655Rb01 | Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IP. |
| PAV655Rb01 | Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV655Rb01 | CLIA Kit for Cluster Of Differentiation 4 (CD4) | CLIA assay for Antigen Detection |
| ELV655Rb01 | ELISA Kit for Cluster Of Differentiation 4 (CD4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV655Mo01 | Recombinant Cluster Of Differentiation 4 (CD4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV655Mo01 | Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IP. |
| PAV655Mo01 | Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV655Mo01 | CLIA Kit for Cluster Of Differentiation 4 (CD4) | CLIA assay for Antigen Detection |
| ELV655Mo01 | ELISA Kit for Cluster Of Differentiation 4 (CD4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Biochemistry 30:2395-2406(1991) [PubMed] [Europe PMC] [Abstract]
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Cell 76:853-864(1994) [PubMed] [Europe PMC] [Abstract]
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Proc. Natl. Acad. Sci. U.S.A. 91:3872-3876(1994) [PubMed] [Europe PMC] [Abstract]
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J. Biol. Chem. 276:9123-9132(2001) [PubMed] [Europe PMC] [Abstract]
"Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling."
J. Immunol. 170:913-921(2003) [PubMed] [Europe PMC] [Abstract]
"Protein minimization of the gp120 binding region of human CD4."
Biochemistry 44:16192-16202(2005) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains."
Nature 348:411-418(1990) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of an HIV-binding recombinant fragment of human CD4."
Nature 348:419-426(1990) [PubMed] [Europe PMC] [Abstract]
"Dimeric association and segmental variability in the structure of human CD4."
Nature 387:527-530(1997) [PubMed] [Europe PMC] [Abstract]
"Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody."
Nature 393:648-659(1998) [PubMed] [Europe PMC] [Abstract]
"Structural basis for the interaction between focal adhesion kinase and CD4."
J. Mol. Biol. 375:1320-1328(2008) [PubMed] [Europe PMC] [Abstract]