Asialoglycoprotein Receptor 1 (ASGR1)
CLEC4H1; HL-1; ASGPR 1; Asialoglyco protein Receptor; C-type lectin domain family 4 member H1; Hepatic lectin H1
The asialoglycoprotein receptor binds to desialylated (galactosyl-terminal) glycoproteins. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociate.
The ASGR1 gene encodes a glycoprotein that forms the asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells. Partially deglycosylated plasma glycoproteins are efficiently and specifically removed from the circulation via this receptor-ligand complex. Many functional studies describing the kinetics of ligand-binding, internalization, and recycling of such receptors have been performed on the human hepatoma cell line HepG2.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV635Hu01 | Recombinant Asialoglycoprotein Receptor 1 (ASGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV635Hu01 | Monoclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IP. |
| PAV635Hu01 | Polyclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV635Hu01 | CLIA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | CLIA assay for Antigen Detection |
| ELV635Hu01 | ELISA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV635Mu01 | Recombinant Asialoglycoprotein Receptor 1 (ASGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV635Mu01 | Monoclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IP. |
| PAV635Mu01 | Polyclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV635Mu01 | CLIA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | CLIA assay for Antigen Detection |
| ELV635Mu01 | ELISA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV635Ra01 | Recombinant Asialoglycoprotein Receptor 1 (ASGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV635Ra01 | Monoclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IP. |
| PAV635Ra01 | Polyclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV635Ra01 | CLIA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | CLIA assay for Antigen Detection |
| ELV635Ra01 | ELISA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV635Ca01 | Recombinant Asialoglycoprotein Receptor 1 (ASGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV635Ca01 | Monoclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IP. |
| PAV635Ca01 | Polyclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV635Ca01 | CLIA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | CLIA assay for Antigen Detection |
| ELV635Ca01 | ELISA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV635Po01 | Recombinant Asialoglycoprotein Receptor 1 (ASGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV635Po01 | Monoclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IP. |
| PAV635Po01 | Polyclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV635Po01 | CLIA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | CLIA assay for Antigen Detection |
| ELV635Po01 | ELISA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV635Bo01 | Recombinant Asialoglycoprotein Receptor 1 (ASGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV635Bo01 | Monoclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IP. |
| PAV635Bo01 | Polyclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV635Bo01 | CLIA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | CLIA assay for Antigen Detection |
| ELV635Bo01 | ELISA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV635Rb01 | Recombinant Asialoglycoprotein Receptor 1 (ASGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV635Rb01 | Monoclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IP. |
| PAV635Rb01 | Polyclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV635Rb01 | CLIA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | CLIA assay for Antigen Detection |
| ELV635Rb01 | ELISA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV635Mo01 | Recombinant Asialoglycoprotein Receptor 1 (ASGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV635Mo01 | Monoclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IP. |
| PAV635Mo01 | Polyclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV635Mo01 | CLIA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | CLIA assay for Antigen Detection |
| ELV635Mo01 | ELISA Kit for Asialoglycoprotein Receptor 1 (ASGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion."
J. Biol. Chem. 260:1979-1982(1985) [PubMed] [Europe PMC] [Abstract]
"An internal signal sequence: the asialoglycoprotein receptor membrane anchor."
Cell 44:177-185(1986) [PubMed] [Europe PMC] [Abstract]
"A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes."
PLoS ONE 5:E12934-E12934(2010) [PubMed] [Europe PMC] [Abstract]
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Fatty acylation of the rat and human asialoglycoprotein receptors. A conserved cytoplasmic cysteine residue is acylated in all receptor subunits."
J. Biol. Chem. 271:32454-32460(1996) [PubMed] [Europe PMC] [Abstract]
"Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1."
Genomics 77:58-64(2001) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor."
J. Mol. Biol. 300:857-865(2000) [PubMed] [Europe PMC] [Abstract]