Cartilage Oligomeric Matrix Protein (COMP)

MED; EDM1; EPD1; PSACH; THBS5; TSP-5; Pseudoachondroplasia,Epiphyseal Dysplasia 1,Multiple; Thrombospondin 5

SPN	V627
HGNC	2227
MGI	88469
PubMed	18855621
RGD	2378
UniProt	P49747
Wiki	COMP

Cartilage oligomeric matrix protein (COMP) is a member of the thrombospondin family of extracellular matrix proteins. The protein consists of five 87-kDa subunits held together by interchain disulfide bonds, forming a 435-kDa pentameric protein. COMP is expressed in all types of cartilage, vitreous of the eye, tendon, and vascular smooth muscle cells.

Immunohistological staining of articular cartilage has revealed a developmentally regulated localization of COMP to the chondrocyte territorial and interterritorial matrix. COMP binds in a zinc-dependent manner to collagen type I and type II and also to collagen type IX. The thrombospondin family currently includes five members: TSP-1, TSP-2, TSP-3, TSP-4, and COMP (also referred to as TSP-5).

Reference

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