Gastrin (GT)
GAST; GAS; Gastrin component I; Big gastrin; Gastrin component II; Gastrin component III
Gastrin is a major physiological regulator of gastric acid secretion. It also has an important trophic or growth-promoting influence on the gastric mucosa. Gastrin is synthesized in G cells, which are located in gastric pits, primarily in the antrum region of the stomach and binds receptors found predominantly on parietal and enterochromaffin-like cells.In humans, gastrin is a hormone that stimulates secretion of gastric acid by the parietal cells of the stomach.
It is released by G cells in the stomach and duodenum.Gastrin is a linear peptide hormone produced by G cells of the duodenum and in the pyloric antrum of the stomach. In the Zollinger-Ellison syndrome, gastrin is produced at excessive levels, often by a gastrinoma of the antrum or the pancreas.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV601Hu01 | Recombinant Gastrin (GT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV601Hu01 | Monoclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IP. |
| PAV601Hu01 | Polyclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV601Hu01 | CLIA Kit for Gastrin (GT) | CLIA assay for Antigen Detection |
| ELV601Hu01 | ELISA Kit for Gastrin (GT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV601Mu01 | Recombinant Gastrin (GT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV601Mu01 | Monoclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IP. |
| PAV601Mu01 | Polyclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV601Mu01 | CLIA Kit for Gastrin (GT) | CLIA assay for Antigen Detection |
| ELV601Mu01 | ELISA Kit for Gastrin (GT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV601Ra01 | Recombinant Gastrin (GT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV601Ra01 | Monoclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IP. |
| PAV601Ra01 | Polyclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV601Ra01 | CLIA Kit for Gastrin (GT) | CLIA assay for Antigen Detection |
| ELV601Ra01 | ELISA Kit for Gastrin (GT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV601Ca01 | Recombinant Gastrin (GT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV601Ca01 | Monoclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IP. |
| PAV601Ca01 | Polyclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV601Ca01 | CLIA Kit for Gastrin (GT) | CLIA assay for Antigen Detection |
| ELV601Ca01 | ELISA Kit for Gastrin (GT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV601Po01 | Recombinant Gastrin (GT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV601Po01 | Monoclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IP. |
| PAV601Po01 | Polyclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV601Po01 | CLIA Kit for Gastrin (GT) | CLIA assay for Antigen Detection |
| ELV601Po01 | ELISA Kit for Gastrin (GT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV601Bo01 | Recombinant Gastrin (GT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV601Bo01 | Monoclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IP. |
| PAV601Bo01 | Polyclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV601Bo01 | CLIA Kit for Gastrin (GT) | CLIA assay for Antigen Detection |
| ELV601Bo01 | ELISA Kit for Gastrin (GT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV601Rb01 | Recombinant Gastrin (GT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV601Rb01 | Monoclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IP. |
| PAV601Rb01 | Polyclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV601Rb01 | CLIA Kit for Gastrin (GT) | CLIA assay for Antigen Detection |
| ELV601Rb01 | ELISA Kit for Gastrin (GT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV601Mo01 | Recombinant Gastrin (GT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV601Mo01 | Monoclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IP. |
| PAV601Mo01 | Polyclonal Antibody to Gastrin (GT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV601Mo01 | CLIA Kit for Gastrin (GT) | CLIA assay for Antigen Detection |
| ELV601Mo01 | ELISA Kit for Gastrin (GT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Expression of human gastrin gene in normal and gastrinoma tissues."
Gene 50:345-352(1986) [PubMed] [Europe PMC] [Abstract]
"Structural analysis of the gene encoding human gastrin: the large intron contains an Alu sequence."
Proc. Natl. Acad. Sci. U.S.A. 81:4662-4666(1984) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of the human gastrin gene."
Nucleic Acids Res. 11:8197-8203(1983) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of human gastrin cDNA: evidence for evolution of gastrin by gene duplication."
Proc. Natl. Acad. Sci. U.S.A. 80:2866-2869(1983) [PubMed] [Europe PMC] [Abstract]
"Structure of a human gastrin gene."
Proc. Natl. Acad. Sci. U.S.A. 81:1067-1069(1984) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of human gastrin precursor cDNA."
Gene 26:53-57(1983) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of gastrin component I as gastrin-71. The largest possible bioactive progastrin product."
Eur. J. Biochem. 223:765-773(1994) [PubMed] [Europe PMC] [Abstract]
"Structures of human gastrins I and II."
Nature 209:583-585(1966) [PubMed] [Europe PMC] [Abstract]
"Purification and structural determination of urinary NH2-terminal big gastrin fragments."
Biochem. Biophys. Res. Commun. 160:1364-1370(1989) [PubMed] [Europe PMC] [Abstract]
"Aminoacid constitution of two gastrins isolated from Zollinger-Ellison tumour tissue."
Gut 10:603-608(1969) [PubMed] [Europe PMC] [Abstract]
"The human gastrin precursor. Characterization of phosphorylated forms and fragments."
Biochem. J. 256:951-957(1988) [PubMed] [Europe PMC] [Abstract]
"Post-poly(Glu) cleavage and degradation modified by O-sulfated tyrosine: a novel post-translational processing mechanism."
EMBO J. 14:389-396(1995) [PubMed] [Europe PMC] [Abstract]
"Tyrosine O-sulfation promotes proteolytic processing of progastrin."
EMBO J. 14:3073-3079(1995) [PubMed] [Europe PMC] [Abstract]
"Metabolism and acid secretory effect of sulfated and nonsulfated gastrin-6 in humans."
Am. J. Physiol. 279:G903-G909(2000) [PubMed] [Europe PMC] [Abstract]