Keratin 19 (KRT19)
K19; CK19; K1CS; Cytokeratin 19; 40-kDa Keratin Intermediate Filament; Keratin, type I cytoskeletal 19
Keratin, type I cytoskeletal 19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains.
Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelops the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.Keratin 19 is a type I cytokeratin.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV587Hu01 | Recombinant Keratin 19 (KRT19) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV587Hu01 | Monoclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IP. |
| PAV587Hu01 | Polyclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV587Hu01 | CLIA Kit for Keratin 19 (KRT19) | CLIA assay for Antigen Detection |
| ELV587Hu01 | ELISA Kit for Keratin 19 (KRT19) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV587Mu01 | Recombinant Keratin 19 (KRT19) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV587Mu01 | Monoclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IP. |
| PAV587Mu01 | Polyclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV587Mu01 | CLIA Kit for Keratin 19 (KRT19) | CLIA assay for Antigen Detection |
| ELV587Mu01 | ELISA Kit for Keratin 19 (KRT19) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV587Ra01 | Recombinant Keratin 19 (KRT19) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV587Ra01 | Monoclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IP. |
| PAV587Ra01 | Polyclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV587Ra01 | CLIA Kit for Keratin 19 (KRT19) | CLIA assay for Antigen Detection |
| ELV587Ra01 | ELISA Kit for Keratin 19 (KRT19) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV587Ca01 | Recombinant Keratin 19 (KRT19) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV587Ca01 | Monoclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IP. |
| PAV587Ca01 | Polyclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV587Ca01 | CLIA Kit for Keratin 19 (KRT19) | CLIA assay for Antigen Detection |
| ELV587Ca01 | ELISA Kit for Keratin 19 (KRT19) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV587Po01 | Recombinant Keratin 19 (KRT19) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV587Po01 | Monoclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IP. |
| PAV587Po01 | Polyclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV587Po01 | CLIA Kit for Keratin 19 (KRT19) | CLIA assay for Antigen Detection |
| ELV587Po01 | ELISA Kit for Keratin 19 (KRT19) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV587Bo01 | Recombinant Keratin 19 (KRT19) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV587Bo01 | Monoclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IP. |
| PAV587Bo01 | Polyclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV587Bo01 | CLIA Kit for Keratin 19 (KRT19) | CLIA assay for Antigen Detection |
| ELV587Bo01 | ELISA Kit for Keratin 19 (KRT19) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV587Rb01 | Recombinant Keratin 19 (KRT19) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV587Rb01 | Monoclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IP. |
| PAV587Rb01 | Polyclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV587Rb01 | CLIA Kit for Keratin 19 (KRT19) | CLIA assay for Antigen Detection |
| ELV587Rb01 | ELISA Kit for Keratin 19 (KRT19) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV587Mo01 | Recombinant Keratin 19 (KRT19) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV587Mo01 | Monoclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IP. |
| PAV587Mo01 | Polyclonal Antibody to Keratin 19 (KRT19) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV587Mo01 | CLIA Kit for Keratin 19 (KRT19) | CLIA assay for Antigen Detection |
| ELV587Mo01 | ELISA Kit for Keratin 19 (KRT19) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Sequence of cDNA coding for human keratin 19."
Nucleic Acids Res. 15:10058-10058(1987) [PubMed] [Europe PMC] [Abstract]
"Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene."
Eur. J. Cell Biol. 47:300-319(1988) [PubMed] [Europe PMC] [Abstract]
"Sequence of the human 40-kDa keratin reveals an unusual structure with very high sequence identity to the corresponding bovine keratin."
Proc. Natl. Acad. Sci. U.S.A. 85:1114-1118(1988) [PubMed] [Europe PMC] [Abstract]
"Keratin 19: predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins."
J. Invest. Dermatol. 92:707-716(1989) [PubMed] [Europe PMC] [Abstract]
"Genomic organization and amplification of the human keratin 15 and 19 genes."
Biochem. Biophys. Res. Commun. 267:462-465(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of the 5'-flanking region of human cytokeratin 19 gene in human cholangiocarcinoma cell line."
J. Hepatol. 35:504-511(2001) [PubMed] [Europe PMC] [Abstract]
"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
"Diversity of keratin 19 gene expressed in lymph nodes of breast cancer patients -- strategy to clear the discrepancy between histological findings and RT-PCR results in the detection of micrometastasis."
Seibutsu Butsuri Kagaku 44:201-204(2000)
"Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization."
J. Biol. Chem. 274:12861-12866(1999) [PubMed] [Europe PMC] [Abstract]
"Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus."
J. Biol. Chem. 275:14910-14915(2000) [PubMed] [Europe PMC] [Abstract]
"Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19."
Mol. Biol. Cell 16:4280-4293(2005) [PubMed] [Europe PMC] [Abstract]
"Characterization of in vivo keratin 19 phosphorylation on tyrosine-391."
PLoS ONE 5:E13538-E13538(2010) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]