Keratin 20 (KRT20)
CK20; Cytokeratin 20; Protein IT; Keratin, type I cytoskeletal 20
Cytokeratin 20(CK20) is a major cellular protein of mature enterocytes and goblet cells commonly found in mucosal epithelium of the mammalian gastrointestinal tract. Results strongly suggest that transcriptional regulation of keratin genes in the intestinal epithelium occurs at the level of both immature and terminally differentiated epithelial cells, and is tightly regulated during both fetal development and crypt-to-villus differentiation of the intestinal epithelium.
CK20 has recently been reported to be useful to distinguish between primary and metastatic lung adenocarcinoma. CK20 expression was significantly more prevalent in adenocarcinoma that originated in the GI tract than that of pulmonary or breast origin.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV586Hu01 | Recombinant Keratin 20 (KRT20) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV586Hu01 | Monoclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IP. |
| PAV586Hu01 | Polyclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV586Hu01 | CLIA Kit for Keratin 20 (KRT20) | CLIA assay for Antigen Detection |
| ELV586Hu01 | ELISA Kit for Keratin 20 (KRT20) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV586Mu01 | Recombinant Keratin 20 (KRT20) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV586Mu01 | Monoclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IP. |
| PAV586Mu01 | Polyclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV586Mu01 | CLIA Kit for Keratin 20 (KRT20) | CLIA assay for Antigen Detection |
| ELV586Mu01 | ELISA Kit for Keratin 20 (KRT20) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV586Ra01 | Recombinant Keratin 20 (KRT20) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV586Ra01 | Monoclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IP. |
| PAV586Ra01 | Polyclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV586Ra01 | CLIA Kit for Keratin 20 (KRT20) | CLIA assay for Antigen Detection |
| ELV586Ra01 | ELISA Kit for Keratin 20 (KRT20) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV586Ca01 | Recombinant Keratin 20 (KRT20) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV586Ca01 | Monoclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IP. |
| PAV586Ca01 | Polyclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV586Ca01 | CLIA Kit for Keratin 20 (KRT20) | CLIA assay for Antigen Detection |
| ELV586Ca01 | ELISA Kit for Keratin 20 (KRT20) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV586Po01 | Recombinant Keratin 20 (KRT20) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV586Po01 | Monoclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IP. |
| PAV586Po01 | Polyclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV586Po01 | CLIA Kit for Keratin 20 (KRT20) | CLIA assay for Antigen Detection |
| ELV586Po01 | ELISA Kit for Keratin 20 (KRT20) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV586Bo01 | Recombinant Keratin 20 (KRT20) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV586Bo01 | Monoclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IP. |
| PAV586Bo01 | Polyclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV586Bo01 | CLIA Kit for Keratin 20 (KRT20) | CLIA assay for Antigen Detection |
| ELV586Bo01 | ELISA Kit for Keratin 20 (KRT20) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV586Rb01 | Recombinant Keratin 20 (KRT20) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV586Rb01 | Monoclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IP. |
| PAV586Rb01 | Polyclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV586Rb01 | CLIA Kit for Keratin 20 (KRT20) | CLIA assay for Antigen Detection |
| ELV586Rb01 | ELISA Kit for Keratin 20 (KRT20) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV586Mo01 | Recombinant Keratin 20 (KRT20) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV586Mo01 | Monoclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IP. |
| PAV586Mo01 | Polyclonal Antibody to Keratin 20 (KRT20) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV586Mo01 | CLIA Kit for Keratin 20 (KRT20) | CLIA assay for Antigen Detection |
| ELV586Mo01 | ELISA Kit for Keratin 20 (KRT20) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas."
Differentiation 53:75-93(1993) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker."
J. Biol. Chem. 281:16453-16461(2006) [PubMed] [Europe PMC] [Abstract]
"Differential localization by in situ hybridization of distinct keratin mRNA species during intestinal epithelial cell development and differentiation."
Differentiation 53:95-104(1993) [PubMed] [Europe PMC] [Abstract]
"Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns."
J. Cell Biol. 111:567-580(1990) [PubMed] [Europe PMC] [Abstract]
"An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium."
Arch. Oral Biol. 45:879-887(2000) [PubMed] [Europe PMC] [Abstract]
"Keratin 20 helps maintain intermediate filament organization in intestinal epithelia."
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Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
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Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]