Sialic Acid Binding Ig Like Lectin 12 (SIGLEC12)

S2V; SIGLECL1; SLG; Siglec-L1; Siglec-XII; Sialic acid-binding Ig-like lectin-like 1

SPN	V581
HGNC	15482
MGI	2681107
PubMed	21555517
UniProt	Q96PQ1
Wiki	SIGLEC12

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins.

This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2.

Reference

"Cloning and molecular characterization of two splice variants of a new putative member of the Siglec-3-like subgroup of Siglecs."
Biochem. Biophys. Res. Commun. 284:887-899(2001) [PubMed] [Europe PMC] [Abstract]

"A second uniquely human mutation affecting sialic acid biology."
J. Biol. Chem. 276:40282-40287(2001) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]