Pancreatic Polypeptide (PP)
PPY; PNP; Pancreatic Polypeptide Y; Obinepitide; Pancreatic icosapeptide; Pancreatic prohormone
Pancreatic polypeptide (PP) is a 36-amino-acid secretory peptide that is predominantly produced by the pancreas. The exact physiologic role of PP in healthy individuals has not been fully defined. This peptide affects the secretion of pancreatic enzymes, water, and electrolytes. Its effect is biphasic in that PP initially enhances secretion and then inhibits secretion. PP increases gastric emptying and gut motility. It also relaxes the pyloric and ileocecocolic sphincters, the colon, and gallbladder. PP levels increase after ngestion of food and remain elevated from 4-8 hours. Prolonged fasting, diabetes, and exercise can also increase PP levels. Serum PP levels can be elevated in as many as 50% of patients with carcinoid syndrome. Increased levels can also be found in patients with duodenal ulcers and in patients with type I diabetes.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV563Hu01 | Recombinant Pancreatic Polypeptide (PP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV563Hu01 | Monoclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IP. |
| PAV563Hu01 | Polyclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV563Hu01 | CLIA Kit for Pancreatic Polypeptide (PP) | CLIA assay for Antigen Detection |
| ELV563Hu01 | ELISA Kit for Pancreatic Polypeptide (PP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV563Mu01 | Recombinant Pancreatic Polypeptide (PP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV563Mu01 | Monoclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IP. |
| PAV563Mu01 | Polyclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV563Mu01 | CLIA Kit for Pancreatic Polypeptide (PP) | CLIA assay for Antigen Detection |
| ELV563Mu01 | ELISA Kit for Pancreatic Polypeptide (PP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV563Ra01 | Recombinant Pancreatic Polypeptide (PP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV563Ra01 | Monoclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IP. |
| PAV563Ra01 | Polyclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV563Ra01 | CLIA Kit for Pancreatic Polypeptide (PP) | CLIA assay for Antigen Detection |
| ELV563Ra01 | ELISA Kit for Pancreatic Polypeptide (PP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV563Ca01 | Recombinant Pancreatic Polypeptide (PP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV563Ca01 | Monoclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IP. |
| PAV563Ca01 | Polyclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV563Ca01 | CLIA Kit for Pancreatic Polypeptide (PP) | CLIA assay for Antigen Detection |
| ELV563Ca01 | ELISA Kit for Pancreatic Polypeptide (PP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV563Po01 | Recombinant Pancreatic Polypeptide (PP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV563Po01 | Monoclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IP. |
| PAV563Po01 | Polyclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV563Po01 | CLIA Kit for Pancreatic Polypeptide (PP) | CLIA assay for Antigen Detection |
| ELV563Po01 | ELISA Kit for Pancreatic Polypeptide (PP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV563Bo01 | Recombinant Pancreatic Polypeptide (PP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV563Bo01 | Monoclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IP. |
| PAV563Bo01 | Polyclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV563Bo01 | CLIA Kit for Pancreatic Polypeptide (PP) | CLIA assay for Antigen Detection |
| ELV563Bo01 | ELISA Kit for Pancreatic Polypeptide (PP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV563Rb01 | Recombinant Pancreatic Polypeptide (PP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV563Rb01 | Monoclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IP. |
| PAV563Rb01 | Polyclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV563Rb01 | CLIA Kit for Pancreatic Polypeptide (PP) | CLIA assay for Antigen Detection |
| ELV563Rb01 | ELISA Kit for Pancreatic Polypeptide (PP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV563Mo01 | Recombinant Pancreatic Polypeptide (PP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV563Mo01 | Monoclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IP. |
| PAV563Mo01 | Polyclonal Antibody to Pancreatic Polypeptide (PP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV563Mo01 | CLIA Kit for Pancreatic Polypeptide (PP) | CLIA assay for Antigen Detection |
| ELV563Mo01 | ELISA Kit for Pancreatic Polypeptide (PP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A cDNA encoding a small common precursor for human pancreatic polypeptide and pancreatic icosapeptide."
EMBO J. 3:909-912(1984) [PubMed] [Europe PMC] [Abstract]
"Exons of the human pancreatic polypeptide gene define functional domains of the precursor."
J. Biol. Chem. 260:13013-13017(1985) [PubMed] [Europe PMC] [Abstract]
"Structure of a precursor to human pancreatic polypeptide."
J. Biol. Chem. 259:14702-14705(1984) [PubMed] [Europe PMC] [Abstract]
"Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7."
J. Clin. Invest. 77:1038-1041(1986) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Human pancreatic icosapeptide: isolation, sequence, and immunocytochemical localization of the COOH-terminal fragment of the pancreatic polypeptide precursor."
Proc. Natl. Acad. Sci. U.S.A. 81:708-712(1984) [PubMed] [Europe PMC] [Abstract]
"Strongly altered receptor binding properties in PP and NPY chimeras are accompanied by changes in structure and membrane binding."
Biochemistry 44:9255-9264(2005) [PubMed] [Europe PMC] [Abstract]