Presenilin 2 (PS2)

PSEN2; AD3L; AD4; PS2; STM2; AD3LP; AD5; Alzheimer Disease 4

SPN	V556
HGNC	9509
MGI	109284
PubMed	8817335
RGD	621060
UniProt	P49810
Wiki	Presenilin_2

Presenilin-2is a protein that is encoded by the PSEN2 gene. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified. In melanocytic cells PSEN2 gene expression may be regulated by MITF.

Reference

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