Fc Fragment Of IgG Low Affinity IIIa Receptor (FcgR3A)

CD16a; CD16-A; FCGR3-A; FCG3; FcgRIII; IGFR3; NA; Neutrophil Antigen; Low affinity immunoglobulin gamma Fc region receptor III-A

SPN	V552
HGNC	3619
MGI	2179523
PubMed	19309690
RGD	1303067
UniProt	P08637
Wiki	FCGR3A

This cell surface antigen(CD16)is identical with hFcRIII (Fc-gamma R3, FCGR3A, FCGR3), an Fc-IgG receptor. CD16 is part of a multimeric complex consisting of three functionally and biochemically distinct proteins that are membrane-spanning subunits mediating assembly and signal transduction. The complex is associated with a protein tyrosine kinase, lck, which is involved also in other signal transduction pathways.

CD16 is one of the three subtypes of Fc-IgG receptors. These receptors are distributed widely on many cells of the immune system and contribute to the pathogenesis of immune complex- and auto-antibody mediated disorders such as vasculitis, rheumatoid arthritis, idiopathic thrombocytopenic purpura or autoimmune neutropenia.

Reference

"Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions."
J. Exp. Med. 170:481-497(1989) [PubMed] [Europe PMC] [Abstract]

"IgG Fc receptor III homologues in nonhuman primate species: genetic characterization and ligand interactions."
J. Immunol. 177:3848-3856(2006) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions."
J. Biol. Chem. 270:1350-1361(1995) [PubMed] [Europe PMC] [Abstract]

"Human glomerular mesangial cells express CD16 and may be stimulated via this receptor."
Kidney Int. 46:1627-1634(1994) [PubMed] [Europe PMC] [Abstract]

"A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms."
Proc. Natl. Acad. Sci. U.S.A. 86:5079-5083(1989) [PubMed] [Europe PMC] [Abstract]

"Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans."
Genes Cells 16:1071-1080(2011) [PubMed] [Europe PMC] [Abstract]

"Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose."
Proc. Natl. Acad. Sci. U.S.A. 108:12669-12674(2011) [PubMed] [Europe PMC] [Abstract]

"A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa."
J. Immunol. 156:2948-2955(1996) [PubMed] [Europe PMC] [Abstract]

"Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype."
Blood 90:1109-1114(1997) [PubMed] [Europe PMC] [Abstract]

"A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease."
J. Clin. Invest. 100:1059-1070(1997) [PubMed] [Europe PMC] [Abstract]

"Identification of an unusual Fc gamma receptor IIIa (CD16) on natural killer cells in a patient with recurrent infections."
Blood 88:3022-3027(1996) [PubMed] [Europe PMC] [Abstract]

"Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II)."
Clin. Exp. Immunol. 103:408-413(1996) [PubMed] [Europe PMC] [Abstract]

"Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity."
J. Clin. Invest. 122:3769-3780(2012) [PubMed] [Europe PMC] [Abstract]