Integrin Alpha 3 (ITGa3)

CD49c; CD49-C; ITG-A3; GAP-B3; GAPB3; MSK18; VCA-2; VL3A; VLA3a; FRP-2; Galactoprotein B3; Alpha 3 Subunit Of VLA-3 Receptor; CD49 antigen-like family member C

SPN	V541
HGNC	6139
MGI	96602
PubMed	24371517
RGD	1310333
UniProt	P26006
Wiki	ITGA3

ITGA3 is an integrin alpha subunit. It makes up half of the α3β1 integrin duplex. ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins.

The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV541Hu01	Recombinant Integrin Alpha 3 (ITGa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV541Hu01	Monoclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IP.
Antibodies	PAV541Hu01	Polyclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IF.
Assay Kits	CLV541Hu01	CLIA Kit for Integrin Alpha 3 (ITGa3)	CLIA assay for Antigen Detection
Assay Kits	ELV541Hu01	ELISA Kit for Integrin Alpha 3 (ITGa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV541Mu01	Recombinant Integrin Alpha 3 (ITGa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV541Mu01	Monoclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IP.
Antibodies	PAV541Mu01	Polyclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IF.
Assay Kits	CLV541Mu01	CLIA Kit for Integrin Alpha 3 (ITGa3)	CLIA assay for Antigen Detection
Assay Kits	ELV541Mu01	ELISA Kit for Integrin Alpha 3 (ITGa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV541Ra01	Recombinant Integrin Alpha 3 (ITGa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV541Ra01	Monoclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IP.
Antibodies	PAV541Ra01	Polyclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IF.
Assay Kits	CLV541Ra01	CLIA Kit for Integrin Alpha 3 (ITGa3)	CLIA assay for Antigen Detection
Assay Kits	ELV541Ra01	ELISA Kit for Integrin Alpha 3 (ITGa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV541Ca01	Recombinant Integrin Alpha 3 (ITGa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV541Ca01	Monoclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IP.
Antibodies	PAV541Ca01	Polyclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IF.
Assay Kits	CLV541Ca01	CLIA Kit for Integrin Alpha 3 (ITGa3)	CLIA assay for Antigen Detection
Assay Kits	ELV541Ca01	ELISA Kit for Integrin Alpha 3 (ITGa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV541Po01	Recombinant Integrin Alpha 3 (ITGa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV541Po01	Monoclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IP.
Antibodies	PAV541Po01	Polyclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IF.
Assay Kits	CLV541Po01	CLIA Kit for Integrin Alpha 3 (ITGa3)	CLIA assay for Antigen Detection
Assay Kits	ELV541Po01	ELISA Kit for Integrin Alpha 3 (ITGa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV541Bo01	Recombinant Integrin Alpha 3 (ITGa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV541Bo01	Monoclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IP.
Antibodies	PAV541Bo01	Polyclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IF.
Assay Kits	CLV541Bo01	CLIA Kit for Integrin Alpha 3 (ITGa3)	CLIA assay for Antigen Detection
Assay Kits	ELV541Bo01	ELISA Kit for Integrin Alpha 3 (ITGa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV541Rb01	Recombinant Integrin Alpha 3 (ITGa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV541Rb01	Monoclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IP.
Antibodies	PAV541Rb01	Polyclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IF.
Assay Kits	CLV541Rb01	CLIA Kit for Integrin Alpha 3 (ITGa3)	CLIA assay for Antigen Detection
Assay Kits	ELV541Rb01	ELISA Kit for Integrin Alpha 3 (ITGa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPV541Mo01	Recombinant Integrin Alpha 3 (ITGa3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAV541Mo01	Monoclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IP.
Antibodies	PAV541Mo01	Polyclonal Antibody to Integrin Alpha 3 (ITGa3)	WB; IHC; ICC; IF.
Assay Kits	CLV541Mo01	CLIA Kit for Integrin Alpha 3 (ITGa3)	CLIA assay for Antigen Detection
Assay Kits	ELV541Mo01	ELISA Kit for Integrin Alpha 3 (ITGa3)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen."
J. Cell Biol. 115:257-266(1991) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3."
J. Biochem. 109:659-665(1991) [PubMed] [Europe PMC] [Abstract]

"Molecular and biological characterization of fusion regulatory proteins (FRPs): anti-FRP mAbs induced HIV-mediated cell fusion via an integrin system."
EMBO J. 13:2044-2055(1994) [PubMed] [Europe PMC] [Abstract]

"The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis."
Proc. Natl. Acad. Sci. U.S.A. 84:3239-3243(1987) [PubMed] [Europe PMC] [Abstract]

"A novel protease-docking function of integrin at invadopodia."
J. Biol. Chem. 274:24947-24952(1999) [PubMed] [Europe PMC] [Abstract]

"The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization."
Lab. Invest. 76:547-563(1997) [PubMed] [Europe PMC] [Abstract]

"Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains."
Biochemistry 42:12950-12959(2003) [PubMed] [Europe PMC] [Abstract]

"Palmitoylation supports assembly and function of integrin-tetraspanin complexes."
J. Cell Biol. 167:1231-1240(2004) [PubMed] [Europe PMC] [Abstract]

"NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin."
Mol. Biol. Cell 15:3580-3590(2004) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Integrin alpha3 mutations with kidney, lung, and skin disease."
N. Engl. J. Med. 366:1508-1514(2012) [PubMed] [Europe PMC] [Abstract]