Complement Component 8b (C8b)
Complement component 8 subunit beta
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.Patients with deficiency of C8 suffer from recurrent neisserial infections, predominantly with meningococcus infection of rare serotypes. Most such patients are discovered among those having their first episode of meningitis at ages older than 10 years. C8 deficiency of the alpha and gamma subunits was found in 4 black families and no Caucasian families by Ross and Densen (1984), whereas C8B deficiency was reported in 12 Caucasian kindreds and no black kindreds. Wulffraat et al. (1994) described a family in which a 13-year-old boy was found to be homozygous for C8B deficiency and to have juvenile chronic arthritis of 6 months' duration.Antinuclear antibodies, anti-double-stranded DNA antibodies, and rheumatoid factor were not detected.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV526Hu01 | Recombinant Complement Component 8b (C8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV526Hu01 | Monoclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IP. |
| PAV526Hu01 | Polyclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV526Hu01 | CLIA Kit for Complement Component 8b (C8b) | CLIA assay for Antigen Detection |
| ELV526Hu01 | ELISA Kit for Complement Component 8b (C8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV526Mu01 | Recombinant Complement Component 8b (C8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV526Mu01 | Monoclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IP. |
| PAV526Mu01 | Polyclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV526Mu01 | CLIA Kit for Complement Component 8b (C8b) | CLIA assay for Antigen Detection |
| ELV526Mu01 | ELISA Kit for Complement Component 8b (C8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV526Ra01 | Recombinant Complement Component 8b (C8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV526Ra01 | Monoclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IP. |
| PAV526Ra01 | Polyclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV526Ra01 | CLIA Kit for Complement Component 8b (C8b) | CLIA assay for Antigen Detection |
| ELV526Ra01 | ELISA Kit for Complement Component 8b (C8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV526Ca01 | Recombinant Complement Component 8b (C8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV526Ca01 | Monoclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IP. |
| PAV526Ca01 | Polyclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV526Ca01 | CLIA Kit for Complement Component 8b (C8b) | CLIA assay for Antigen Detection |
| ELV526Ca01 | ELISA Kit for Complement Component 8b (C8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV526Po01 | Recombinant Complement Component 8b (C8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV526Po01 | Monoclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IP. |
| PAV526Po01 | Polyclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV526Po01 | CLIA Kit for Complement Component 8b (C8b) | CLIA assay for Antigen Detection |
| ELV526Po01 | ELISA Kit for Complement Component 8b (C8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV526Bo01 | Recombinant Complement Component 8b (C8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV526Bo01 | Monoclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IP. |
| PAV526Bo01 | Polyclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV526Bo01 | CLIA Kit for Complement Component 8b (C8b) | CLIA assay for Antigen Detection |
| ELV526Bo01 | ELISA Kit for Complement Component 8b (C8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV526Rb01 | Recombinant Complement Component 8b (C8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV526Rb01 | Monoclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IP. |
| PAV526Rb01 | Polyclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV526Rb01 | CLIA Kit for Complement Component 8b (C8b) | CLIA assay for Antigen Detection |
| ELV526Rb01 | ELISA Kit for Complement Component 8b (C8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV526Mo01 | Recombinant Complement Component 8b (C8b) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV526Mo01 | Monoclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IP. |
| PAV526Mo01 | Polyclonal Antibody to Complement Component 8b (C8b) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV526Mo01 | CLIA Kit for Complement Component 8b (C8b) | CLIA assay for Antigen Detection |
| ELV526Mo01 | ELISA Kit for Complement Component 8b (C8b) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Complementary DNA and derived amino acid sequence of the beta subunit of human complement protein C8: identification of a close structural and ancestral relationship to the alpha subunit and C9."
Biochemistry 26:3565-3570(1987) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Complementary DNA cloning of complement C8 beta and its sequence homology to C9."
Biochemistry 26:3551-3556(1987) [PubMed] [Europe PMC] [Abstract]
"The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure."
J. Biol. Chem. 255:11997-12005(1980) [PubMed] [Europe PMC] [Abstract]
"The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues."
J. Biol. Chem. 274:32786-32794(1999) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement."
J. Biol. Chem. 286:17585-17592(2011) [PubMed] [Europe PMC] [Abstract]
"Human complement component C8. Molecular basis of the beta-chain polymorphism."
FEBS Lett. 340:211-215(1994) [PubMed] [Europe PMC] [Abstract]