Protein Tyrosine Phosphatase Receptor Type O (PTPRO)
PTPR-O; GLEPP1; PTP-U2; PTPU2; Osteoclastic Transmembrane Protein-Tyrosine Phosphatase; Glomerular Epithelial Protein-1; Protein tyrosine phosphatase U2
Receptor-type tyrosine-protein phosphatase O is tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
It is a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif.
The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.
The human GLEPP1 gene predicts a protein of 1,188 amino acids. The 1,159-amino acid predicted mature protein contains a large extracellular domain, a single transmembrane domain, and a single intracellular PTPase domain.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV511Hu01 | Recombinant Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV511Hu01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IP. |
| PAV511Hu01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV511Hu01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | CLIA assay for Antigen Detection |
| ELV511Hu01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV511Mu01 | Recombinant Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV511Mu01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IP. |
| PAV511Mu01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV511Mu01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | CLIA assay for Antigen Detection |
| ELV511Mu01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV511Ra01 | Recombinant Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV511Ra01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IP. |
| PAV511Ra01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV511Ra01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | CLIA assay for Antigen Detection |
| ELV511Ra01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV511Ca01 | Recombinant Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV511Ca01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IP. |
| PAV511Ca01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV511Ca01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | CLIA assay for Antigen Detection |
| ELV511Ca01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV511Po01 | Recombinant Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV511Po01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IP. |
| PAV511Po01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV511Po01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | CLIA assay for Antigen Detection |
| ELV511Po01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV511Bo01 | Recombinant Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV511Bo01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IP. |
| PAV511Bo01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV511Bo01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | CLIA assay for Antigen Detection |
| ELV511Bo01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV511Rb01 | Recombinant Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV511Rb01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IP. |
| PAV511Rb01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV511Rb01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | CLIA assay for Antigen Detection |
| ELV511Rb01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV511Mo01 | Recombinant Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV511Mo01 | Monoclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IP. |
| PAV511Mo01 | Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV511Mo01 | CLIA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | CLIA assay for Antigen Detection |
| ELV511Mo01 | ELISA Kit for Protein Tyrosine Phosphatase Receptor Type O (PTPRO) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents."
Oncogene 10:1731-1738(1995) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13."
Genomics 27:174-181(1995) [PubMed] [Europe PMC] [Abstract]
"PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest."
Blood 94:2403-2413(1999) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Disruption of PTPRO causes childhood-onset nephrotic syndrome."
Am. J. Hum. Genet. 89:139-147(2011) [PubMed] [Europe PMC] [Abstract]
"Large-scale structural analysis of the classical human protein tyrosine phosphatome."
Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
"Structural genomics of protein phosphatases."
J. Struct. Funct. Genomics 8:121-140(2007) [PubMed] [Europe PMC] [Abstract]